The cornea is a tissue susceptible to various injuries and traumas with a complicated cascade repair process, in which conserving its integrity and clarity is critical to restoring visual function. Enhancing the endogenous electric field is recognized as an effective method of accelerating corneal injury repair. However, current equipment limitations and implementation complexities hinder its widespread adoption. Here, we propose a snowflake-inspired, blink-driven flexible piezoelectric contact lens that can convert mechanical blink motions into a unidirectional pulsed electric field for direct application to moderate corneal injury repair. The device is validated on mouse and rabbit models with different relative corneal alkali burn ratios to modulate the microenvironment, alleviate stromal fibrosis, promote orderly epithelial arrangement and differentiation, and restore corneal clarity. Within an 8-day intervention, the corneal clarity of mice and rabbits improves by more than 50%, and the repair rate of mouse and rabbit corneas increases by over 52%. Mechanistically, the device intervention is advantageous in blocking growth factors’ signaling pathways specifically involved in stromal fibrosis whilst preserving and harnessing the signaling pathways required for indispensable epithelial metabolism. This work put forward an efficient and orderly corneal therapeutic technology utilizing artificial endogenous-strengthened signals generated by spontaneous body activities.

角膜是一种容易受到各种损伤和创伤的组织，具有复杂的级联修复过程，其中保持其完整性和清晰度对于恢复视觉功能至关重要。增强内源电场被认为是加速角膜损伤修复的有效方法。然而，当前的设备限制和实施复杂性阻碍了其广泛采用。在这里，我们提出了一种受雪花启发、眨眼驱动的柔性压电隐形眼镜，它可以将机械眨眼运动转换为单向脉冲电场，直接应用于中度角膜损伤修复。该装置在不同相对角膜碱烧伤比例的小鼠和兔模型上进行了验证，可调节微环境，减轻基质纤维化，促进有序上皮排列和分化，恢复角膜清晰度。经过8天的干预，小鼠和兔子的角膜清晰度提高了50%以上，小鼠和兔子的角膜修复率提高了52%以上。从机制上讲，该装置干预有利于阻断特别参与基质纤维化的生长因子信号通路，同时保留和利用不可或缺的上皮代谢所需的信号通路。这项工作提出了一种利用自发身体活动产生的人工内源性强化信号的高效有序的角膜治疗技术。