Brewed green tea, green tea extract, and its primary active compound, epigallocatechin gallate, may interact with drugs and alter the drugʼs therapeutic effectiveness, ultimately leading to therapeutic failure or drug overdose. Several isolated reports have claimed that epigallocatechin gallate is the main active ingredient that causes these effects. While a few studies aimed to uncover evidence of epigallocatechin gallate-drug interactions, no study has thoroughly and collectively reviewed them. Epigallocatechin gallate is a potential cardioprotective agent used by many patients with cardiovascular diseases as a complementary medicine alongside conventional modern medications, either with or without the knowledge of their physicians. Therefore, this review focuses on the impact of concurrent epigallocatechin gallate supplementation on pharmacokinetics and pharmacodynamics of several commonly used cardiovascular drugs (statins, beta-blockers, and calcium channel blockers). The PubMed index was searched for key words related to this review, without year limit, and the results were analyzed for interactions of cardiovascular drugs with epigallocatechin gallate. This review concludes that epigallocatechin gallate increases systemic circulation of several statins (simvastatin, fluvastatin, rosuvastatin) and calcium channel blockers (verapamil), but decreases the bioavailability of beta-blockers (nadolol, atenolol, bisoprolol). Further studies on its clinical significance in affecting drug efficacy are required.

冲泡的绿茶、绿茶提取物及其主要活性化合物表没食子儿茶素没食子酸酯可能与药物相互作用并改变药物的治疗效果，最终导致治疗失败或药物过量。几份孤立的报告声称表没食子儿茶素没食子酸酯是导致这些作用的主要活性成分。虽然一些研究旨在揭示表没食子儿茶素没食子酸酯与药物相互作用的证据，但还没有研究对它们进行彻底和集体的审查。表没食子儿茶素没食子酸酯是一种潜在的心脏保护剂，许多心血管疾病患者将其作为传统现代药物的补充药物，无论医生是否知情。因此，本综述重点关注同时补充表没食子儿茶素没食子酸酯对几种常用心血管药物（他汀类药物、β受体阻滞剂和钙通道阻滞剂）药代动力学和药效学的影响。PubMed索引检索与本综述相关的关键词，不限年份，对结果进行心血管药物与表没食子儿茶素没食子酸酯的相互作用分析。本综述的结论是，表没食子儿茶素没食子酸酯可增加多种他汀类药物（辛伐他汀、氟伐他汀、瑞舒伐他汀）和钙通道阻滞剂（维拉帕米）的体循环，但会降低 β 受体阻滞剂（纳多洛尔、阿替洛尔、比索洛尔）的生物利用度。需要进一步研究其影响药物疗效的临床意义。