Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino Acid Derivatives,Organic Letters

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Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino Acid Derivatives
Organic Letters ( IF 4.9 ) Pub Date : 2023-06-16 , DOI: 10.1021/acs.orglett.3c01760
Yue Dong ₁ , Xiang Meng ₁ , Giri Gnawali ₁ , Mengyang Chang ₂ , Wei Wang _{1,

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Affiliation

A photoredox catalytic asymmetric method has been established for the installation of both aliphatic and aromatic side chains and the introduction of deuterium into the chiral methyleneoxazolidinone simultaneously. Efficient coupling of readily available boronic acids with the chiral auxiliary delivers structurally diverse α-deuterated α-amino acid derivatives with a high level of diastereoselectivity and deuteration.

中文翻译：

烷基/芳基侧链和氘的光氧化还原催化安装到 (S)-亚甲基恶唑烷酮中：对映体富集 α-氘代 α-氨基酸衍生物的合成

建立了一种光氧化还原催化不对称方法，同时在手性亚甲基恶唑烷酮中安装脂肪族和芳香族侧链并引入氘。容易获得的硼酸与手性助剂的有效偶联可产生结构多样的 α-氘代 α-氨基酸衍生物，具有高水平的非对映选择性和氘化。

更新日期：2023-06-16

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