General and Selective Copper-Catalyzed Reduction of Tertiary and Secondary Phosphine Oxides: Convenient Synthesis of Phosphines,Journal of the American Chemical Society

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General and Selective Copper-Catalyzed Reduction of Tertiary and Secondary Phosphine Oxides: Convenient Synthesis of Phosphines
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2012-05-30 , DOI: 10.1021/ja301764m
Yuehui Li ₁ , Shoubhik Das ₁ , Shaolin Zhou ₁ , Kathrin Junge ₁ , Matthias Beller ₁

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Novel catalytic reductions of tertiary and secondary phosphine oxides to phosphines have been developed. Using tetramethyldisiloxane (TMDS) as a mild reducing agent in the presence of copper complexes, PO bonds are selectively reduced in the presence of other reducible functional groups (FGs) such as ketones, esters, and olefins. Based on this transformation, an efficient one pot reduction/phosphination domino sequence allows for the synthesis of a variety of functionalized aromatic and aliphatic phosphines in good yields.

中文翻译：

三级和二级氧化膦的一般和选择性铜催化还原：方便合成膦

已经开发了将叔和仲氧化膦新型催化还原为膦的方法。在铜配合物的存在下使用四甲基二硅氧烷 (TMDS) 作为温和的还原剂，PO 键在其他可还原的官能团 (FG) 的存在下被选择性还原，例如酮、酯和烯烃。基于这种转化，有效的一锅还原/膦化多米诺序列允许以良好的产率合成各种官能化的芳族和脂肪族膦。

更新日期：2012-05-30

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