加兰香内酯及其转化产物加兰香酮的生态风险：来自文献的证据和广州航道的案例研究,Environmental Science: Processes & Impacts

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加兰香内酯及其转化产物加兰香酮的生态风险：来自文献的证据和广州航道的案例研究
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2023-06-14 , DOI: 10.1039/d3em00139c
Yanrong Su ₁ , Faxu Li ₁ , Xiangxiang Xiao ₁ , Huizhen Li ₁ , Dali Wang ₁ , Jing You ₁

Affiliation

Galaxolidone (HHCB-lac) 是常用的合成麝香半乳糖苷 (HHCB) 的主要转化产物，与母体化合物一起普遍存在于环境中。尽管许多研究已经表明HHCB的有害影响，但很少有人关注HHCB-lac的潜在生态风险。在此，我们回顾了文献报道的不同介质中 HHCB 和 HHCB-lac (HHCB-lac : HHCB) 的浓度和比例，利用 ECOSAR 预测和物种敏感性分布推导出这两种化合物的预测无效应浓度 (PNEC) （SSD）估计并评估其在水生环境中的生态风险。文献数据表明，HHCB-lac和HHCB在环境中的存在比例一般为0.01-10。使用衍生的PNEC（HHCB和HHCB-lac分别为2.14和18.4 μg L ^-1），水生环境中的HHCB被评估为具有中到高风险，而HHCB-lac被评估为具有低风险。此外，我们还对广州水道中HHCB和HHCB-lac的发生和生态风险进行了案例研究。广州水道中两种化合物的浓度范围分别为20～2620 ng L ^-1和3～740 ng L ^-1，比值范围为0.15～0.64。现场研究数据还显示，HHCB 具有中到高风险，HHCB-lac 具有低风险。此外，HHCB 和 HHCB-lac 的内分泌影响得到了 Endocrine Disruptome 的证实，这要求对 HHCB 和 HHCB-lac 对人类健康的潜在影响进行更严格的审查。

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Ecological risk of galaxolide and its transformation product galaxolidone: evidence from the literature and a case study in Guangzhou waterways

Galaxolidone (HHCB-lac) is a major transformation product of the commonly used synthetic musk galaxolide (HHCB) and is ubiquitous in the environment along with the parent compound. Although many studies have shown the harmful effects of HHCB, little attention has been paid to the potential ecological risk of HHCB-lac. Herein, we reviewed the concentrations and ratios of HHCB and HHCB-lac (HHCB-lac : HHCB) in different media reported in the literature, derived the predicted no-effect concentrations (PNECs) for the two compounds using ECOSAR predictions and species sensitivity distribution (SSD) estimates, and assessed their ecological risks in the aquatic environment. The literature data indicated that HHCB-lac and HHCB were generally present in the environment at ratios of 0.01–10. Using the derived PNECs (2.14 and 18.4 μg L⁻¹ for HHCB and HHCB-lac, respectively), HHCB in the aquatic environment was assessed to have medium to high risks, while HHCB-lac was assessed to have low risks. Furthermore, we carried out a case study on the occurrence and ecological risks of HHCB and HHCB-lac in Guangzhou waterways. The concentrations of the two compounds in Guangzhou waterways ranged from 20 to 2620 ng L⁻¹ and 3 to 740 ng L⁻¹, respectively, and the ratios were in the range of 0.15 to 0.64. The field study data also showed medium to high risks of HHCB and low risks of HHCB-lac. Additionally, the endocrine effects of HHCB and HHCB-lac were confirmed by Endocrine Disruptome, which calls for greater scrutiny of the potential effects of HHCB and HHCB-lac on human health.

更新日期：2023-06-14

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