Horsfielenigans A and B, Two Rearranged Lignans with Anti-Inflammatory Effects from Horsfieldia kingii,Chemistry & Biodiversity

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Horsfielenigans A and B, Two Rearranged Lignans with Anti-Inflammatory Effects from Horsfieldia kingii
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-06-13 , DOI: 10.1002/cbdv.202300549
Xian-Huan Zhang ₁ , Zhao Lu ₁ , Zhi-Yuan Li ₂ , Nan Fu ₁ , Rui Zhan ₁

Affiliation

Seven lignans were isolated from 70 % aqueous acetone extracts of the twigs and leaves of Horsfieldia kingii. Among these, new compounds 1–3 were identified by spectroscopic techniques, with horsfielenigans A and B (1 and 2) being particularly noteworthy for their rare β-benzylnaphthalene skeleton, where compound 1 contains an oxabicyclo[3,2,1]octane moiety. In vitro evaluation of bioactivity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages revealed inhibitory effects by 1 (IC₅₀=7.3 μM) and 2 (IC₅₀=9.7 μM).

中文翻译：

Horsfielenigans A 和 B，来自 Horsfieldia kingii 的两种具有抗炎作用的重排木脂素

从Horsfieldia kingii的嫩枝和叶的70%丙酮水提取物中分离出7种木酚素。其中，通过光谱技术鉴定出新化合物1 – 3 ，其中 horsfielenigans A 和 B（ 1和2 ）因其罕见的β-苄基萘骨架而特别值得注意，其中化合物1含有氧杂双环[3,2,1]辛烷部分。对 LPS 激活的 RAW264.7 巨噬细胞中一氧化氮 (NO) 产生的生物活性进行体外评估，结果显示1 (IC ₅₀ =7.3 μM) 和2 (IC ₅₀ =9.7 μM) 具有抑制作用。

更新日期：2023-06-13

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