Current State of Microflow Trifluoromethylation Reactions,The Chemical Record

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Current State of Microflow Trifluoromethylation Reactions
The Chemical Record ( IF 7.0 ) Pub Date : 2023-06-12 , DOI: 10.1002/tcr.202300117
Yuji Sumii ₁ , Norio Shibata _{1,

2}

Affiliation

The trifluoromethyl group is a powerful structural motif in drugs and polymers; thus, developing trifluoromethylation reactions is an important area of research in organic chemistry. Over the past few decades, significant progress has been made in developing new methods for the trifluoromethylation of organic molecules, ranging from nucleophilic and electrophilic approaches to transition-metal catalysis, photocatalysis, and electrolytic reactions. While these reactions were initially developed in batch systems, more recent microflow versions are highly attractive for industrial applications owing to their scalability, safety, and time efficiency. In this review, we discuss the current state of microflow trifluoromethylation. Approaches for microflow trifluoromethylation based on different trifluoromethylation reagents are described, including continuous flow, flow photochemical, microfluidic electrochemical reactions, and large-scale microflow reactions.

中文翻译：

微流三氟甲基化反应的现状

三氟甲基是药物和聚合物中强大的结构基序；因此，发展三氟甲基化反应是有机化学研究的一个重要领域。在过去的几十年中，在开发有机分子三氟甲基化的新方法方面取得了重大进展，从亲核和亲电方法到过渡金属催化、光催化和电解反应。虽然这些反应最初是在批量系统中开发的，但最近的微流版本由于其可扩展性、安全性和时间效率而对工业应用极具吸引力。在这篇综述中，我们讨论了微流三氟甲基化的现状。描述了基于不同三氟甲基化试剂的微流三氟甲基化方法，

更新日期：2023-06-12

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