Clerodane 型二萜的抗炎和细胞毒活性,Molecules

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Clerodane 型二萜的抗炎和细胞毒活性
Molecules ( IF 4.2 ) Pub Date : 2023-06-13 , DOI: 10.3390/molecules28124744
Rubria Marlen Martínez-Casares ₁ , Liliana Hernández-Vázquez ₁ , Angelica Mandujano ₂ , Leonor Sánchez-Pérez ₂ , Salud Pérez-Gutiérrez ₁ , Julia Pérez-Ramos ₁

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已在不同科的多种植物物种和其他生物体中发现了氯丹二萜的次生代谢产物。在本次综述中，我们纳入了 2015 年至 2023 年 2 月有关具有细胞毒性或抗炎活性的 clerodane 和 neo-clerodanes 的文章。在以下数据库中进行了搜索：PubMed、Google Scholar 和 Science Direct，使用关键词 clerodane 或 neo-具有细胞毒性或抗炎活性的clerodanes。在这项工作中，我们对来自 7 个科 18 个物种的具有抗炎作用的二萜和来自 9 个科 25 个物种的具有细胞毒活性的二萜进行了研究。这些植物大多来自唇形科、杨柳科、防己科和大戟科。总之，Clerodane 二萜具有针对不同细胞癌细胞系的活性。与当今已知的多种 Clerodane 相关的特定抗增殖机制已被描述，因为许多此类化合物已被识别，其中一些我们几乎不知道它们的特性。很可能存在比今天描述的化合物还要多的化合物，这使得它成为一个有待发现的开放领域。此外，本综述中提出的一些二萜具有已知的治疗靶点，因此可以通过某种方式预测它们潜在的副作用。以这样的方式使其成为一个开放的探索领域。此外，本综述中提出的一些二萜具有已知的治疗靶点，因此可以通过某种方式预测它们潜在的副作用。以这样的方式使其成为一个开放的探索领域。此外，本综述中提出的一些二萜具有已知的治疗靶点，因此可以通过某种方式预测它们潜在的副作用。

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Anti-Inflammatory and Cytotoxic Activities of Clerodane-Type Diterpenes

The secondary metabolites of clerodane diterpenoids have been found in several plant species from various families and in other organisms. In this review, we included articles on clerodanes and neo-clerodanes with cytotoxic or anti-inflammatory activity from 2015 to February 2023. A search was conducted in the following databases: PubMed, Google Scholar and Science Direct, using the keywords clerodanes or neo-clerodanes with cytotoxicity or anti-inflammatory activity. In this work, we present studies on these diterpenes with anti-inflammatory effects from 18 species belonging to 7 families and those with cytotoxic activity from 25 species belonging to 9 families. These plants are mostly from the Lamiaceae, Salicaceae, Menispermaceae and Euphorbiaceae families. In summary, clerodane diterpenes have activity against different cell cancer lines. Specific antiproliferative mechanisms related to the wide range of clerodanes known today have been described, since many of these compounds have been identified, some of which we barely know their properties. It is very possible that there are even more compounds than those described today, in such a way that makes it an open field to discover. Furthermore, some diterpenes presented in this review have already-known therapeutic targets, and therefore, their potential adverse effects can be predicted in some way.

更新日期：2023-06-13

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