Ruptenes: A Family of Terpene Analogs Give Insight into Cyclisation Mechanisms by Cascade Disruption,Angewandte Chemie International Edition

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Ruptenes: A Family of Terpene Analogs Give Insight into Cyclisation Mechanisms by Cascade Disruption
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-06-12 , DOI: 10.1002/anie.202307006
Binbin Gu ₁ , Jeroen S Dickschat ₁

Affiliation

Two terpenoid substrate analogs with a saturated C6−C7 bond were converted with terpene synthases. Their blocked reactivity caused interruption of the cyclisation cascade leading to ruptenes that represent cationic intermediates of the natural cyclisation reaction. Such intermediates are difficult to observe directly and thus the ruptenes deepen our understanding of terpene synthase catalysis.

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