N⁶-methyladenosine (m⁶A) is the most common mRNA modification in mammalians. The function and dynamic regulation of m⁶A depends on the “writer”, “readers” and “erasers”. YT521-B homology domain family (YTHDF) is a class of m⁶A binding proteins, including YTHDF1, YTHDF2 and YTHDF3. In recent years, the modification of m⁶A and the molecular mechanism of YTHDFs have been further understood. Growing evidence has shown that YTHDFs participate in multifarious bioprocesses, particularly tumorigenesis. In this review, we summarized the structural characteristics of YTHDFs, the regulation of mRNA by YTHDFs, the role of YTHDF proteins in human cancers and inhibition of YTHDFs.

N ⁶ -甲基腺苷 (m ⁶ A) 是哺乳动物中最常见的 mRNA 修饰。^{m 6} A的功能和动态调节取决于“写入器”、“读取器”和“擦除器”。YT521-B同源结构域家族(YTHDF)是一类m ⁶ A结合蛋白，包括YTHDF1、YTHDF2和YTHDF3。近年来，m ⁶ A的修饰和YTHDFs的分子机制得到了进一步的了解。越来越多的证据表明，YTHDF 参与多种生物过程，特别是肿瘤发生。在这篇综述中，我们总结了 YTHDF 的结构特征、YTHDF 对 mRNA 的调节、YTHDF 蛋白在人类癌症中的作用以及 YTHDF 的抑制作用。