Terbinafine, an inhibitor of squalene epoxidase in ergosterol biosynthesis, is chiefly utilized as an antifungal medication with potential uses in pesticide applications. This study explores the fungicidal efficacy of terbinafine against prevalent plant pathogens and confirms its effectiveness. To augment its water solubility, five ionic salts of terbinafine were synthesized by pairing them with organic acids. Among these salts, TIS 5 delivered the most impressive results, amplifying the water solubility of terbinafine by three orders of magnitude and lessening its surface tension to facilitate better dispersion during spraying. The in vivo experiments on cherry tomatoes showed that TIS 5 had a superior therapeutic activity compared to its parent compound and two commonly used broad−spectrum fungicides, pyraclostrobin and carbendazim. The results highlight the potential of terbinafine and its ionic salts, particularly TIS 5, for use as fungicides in agriculture due to their synergistic effects with furan−2−carboxylate.

中文翻译：

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特比萘芬及其离子盐对某些真菌植物病原体的作用

特比萘芬是麦角甾醇生物合成中角鲨烯环氧酶的抑制剂，主要用作抗真菌药物，在农药应用中具有潜在用途。本研究探讨了特比萘芬对常见植物病原体的杀菌功效并证实了其有效性。为了增加其水溶性，通过与有机酸配对合成了特比萘芬的五种离子盐。在这些盐中，TIS 5 取得了最令人印象深刻的结果，将特比萘芬的水溶性提高了三个数量级，并降低了其表面张力，以促进喷雾过程中更好的分散。樱桃番茄的体内实验表明，TIS 5 与其母体化合物以及两种常用的广谱杀菌剂唑菌胺酯和多菌灵相比具有优异的治疗活性。