Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-06-09 , DOI: 10.1002/adfm.202301138
Rui‐Liang Ge ₁ , Pei‐Ning Yan ₂ , Yang Liu ₂ , Zhi‐Shuai Li ₂ , Shu‐Qun Shen ₂ , Yong Yu ₂

Affiliation

Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is a treatment strategy that utilizes near-infrared (NIR) light-induced photothermal agents (PTAs) to yield photothermal effects to localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks to timely summarize and highlight the recent progress of PTAs used for photothermal treatment of liver cancer in vivo and in vitro in the last five-year. The implications of various PTAs on the multifunctional photothermal conversion capability, the structure-performance correlations of PTT, together with the evaluation of their potential in application are systematically dissected to further dig out what the buried mechanism is. Besides, higher requirements are put forward for the discrepancies and crucial issues faced by different PTAs in PTT with related medical technical obstacles being conquered, which lays a solid theoretical foundation for the medical field of oncology treatment as a whole, especially liver cancer. Finally, it is expected that this review can present valuable guidance for the design of efficient, photostability, and biosafety-aware PTAs for anticancer therapy while stepping into the fast traffic lane for the conversion from bench to bedside in the foreseeable future.

中文翻译：

近红外光热转换材料光热治疗肝细胞癌的最新进展和临床潜力

人们越来越关注光热肿瘤治疗 (PTT) 作为传统肝癌治疗的一种有希望的替代方案，这是一种利用近红外 (NIR) 光诱导光热剂 (PTA) 产生光热效应以局部肿瘤热损伤的治疗策略。鉴于实验研究与临床应用之间的差距，本文旨在及时总结和重点介绍近五年来PTAs用于肝癌体内和体外光热治疗的最新进展。系统地剖析了各种 PTA 对多功能光热转换能力的影响、PTT 的结构与性能相关性以及对其应用潜力的评估，以进一步挖掘隐藏的机制。除了，针对PTT中不同PTA所面临的差异和关键问题提出了更高的要求，相关医疗技术障碍的攻克，为整个肿瘤特别是肝癌治疗的医学领域奠定了坚实的理论基础。最后，预计该综述可以为抗癌治疗的高效、光稳定性和生物安全意识 PTA 的设计提供有价值的指导，同时在可预见的将来步入从实验室到临床转化的快车道。

更新日期：2023-06-09

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南