Urothelial carcinoma (UC) is a common type of human cancer and, although urine cytology is a useful method for identifying high-grade UC (HGUC), its ability to diagnose low-grade UC (LGUC) is limited. The authors previously reported that annexin A10 (ANXA10) expression was strongly linked to both papillary and early stage LGUC and was inversely correlated with p53 expression in upper tract UC (UTUC) and bladder UC. However, it remains largely unknown whether ANXA10 is useful as a diagnostic marker for urine cytology.

中文翻译：

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低级别尿路上皮癌和乳头状尿路上皮癌中膜联蛋白 A10 和 p53 的双重免疫细胞化学染色有助于提高尿细胞学诊断的准确性

尿路上皮癌 (UC) 是一种常见的人类癌症，尽管尿液细胞学是识别高级别 UC (HGUC) 的有用方法，但其诊断低级别 UC (LGUC) 的能力有限。作者之前报道，膜联蛋白 A10 (ANXA10) 表达与乳头状和早期 LGUC 密切相关，并且与上尿路 UC (UTUC) 和膀胱 UC 中 p53 表达呈负相关。然而，ANXA10 是否可用作尿液细胞学诊断标记物仍然很大程度上未知。