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Stable Chitosan and Prussian Blue-Coated Laser-Induced Graphene Skin Sensor for the Electrochemical Detection of Hydrogen Peroxide in Sweat
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-06-08 , DOI: 10.1021/acsanm.3c01199
Robert Barber 1 , James Davis 1 , Pagona Papakonstantinou 1
Affiliation  

Developing a noninvasive skin peroxide monitoring technology is highly desirable for managing a number of metabolic disorders associated with diabetes, pulmonary diseases, or other health conditions. To date, the majority of studies on peroxide detection have been conducted on simulated sweat and high pH conditions, which are beyond the physiological range, in order to provide an enhanced response. Here, a skin-worn amperometric sensor, based on laser-induced graphene (LIG), surface-engineered with a Prussian blue (PB)–chitosan (CS) network was fabricated by one-step electrodeposition for the stable and sensitive detection of H2O2 in human eccrine perspiration. The hybrid (PB–CS) network and laser-written electrode configuration were optimized through systematic investigation of electrodeposition parameters and concurrent feedback from electrochemical and morphological characterization at each fabrication step. Different from the multitude of carbon-based electrodes functionalized with metallic nanoparticles reported in the literature, the sensor was operated at a low potential of −0.036 V vs Ag/AgCl in unmodified human eccrine perspiration. The low working potential ensured that the sensor is highly specific, immune to the current from oxygen reduction or common interfering species, whereas the inclusion of CS in the hybrid coating afforded a highly stable performance over a period of 14 days. The sensor was able to monitor H2O2 over the linear range of 10–1000 μM with a low detection limit of 6.31 μM and achieved a recovery of 98.73% (%RSD 0.86) in human eccrine perspiration. This facile biosensor based on directly laser-written electrodes coupled with the one-step PB–CS fabrication strategy has the potential to form the basis for the development of oxidase enzyme-based sensors in sweat.

中文翻译:

稳定的壳聚糖和普鲁士蓝涂层激光诱导石墨烯皮肤传感器用于电化学检测汗液中的过氧化氢

开发一种非侵入性皮肤过氧化物监测技术对于管理与糖尿病、肺部疾病或其他健康状况相关的许多代谢紊乱非常有必要。迄今为止,大多数过氧化物检测研究都是在模拟汗液和高 pH 条件下进行的,这些条件超出了生理范围,以提供增强的响应。在这里,一种基于激光诱导石墨烯 (LIG) 的皮肤佩戴式电流传感器,采用普鲁士蓝 (PB)-壳聚糖 (CS) 网络进行表面设计,通过一步电沉积法制造,用于稳定、灵敏地检测 H 22在人类小汗腺中。通过对电沉积参数的系统研究以及每个制造步骤的电化学和形态表征的并发反馈,优化了混合(PB-CS)网络和激光写入电极配置。与文献中报道的众多用金属纳米粒子功能化的碳基电极不同,该传感器在未经修饰的人类小汗腺汗液中以-0.036 V vs Ag/AgCl的低电位运行。低工作电位确保了传感器具有高度特异性,不受氧还原或常见干扰物质产生的电流的影响,而混合涂层中包含的CS可在14天内提供高度稳定的性能。该传感器能够监测 H 2 O2在 10–1000 μM 的线性范围内检测限低至 6.31 μM,在人类小汗腺汗液中实现了 98.73% (%RSD 0.86) 的回收率。这种基于直接激光写入电极的简便生物传感器与一步式 PB-CS 制造策略相结合,有可能为汗液中基于氧化酶的传感器的开发奠定基础。
更新日期:2023-06-08
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