Metal-organic frameworks (MOFs) are a prominent porous material for cancer biomarkers detection. They are enriched with unique features of permanent porosity and tunable pore size, leading to their efficient use in biosensing. In this review, we have summarized and studied MOF materials for the electrochemical detection of cancer biomarkers. First, insight into the tunable porosity and surface areas have been discussed to explore the applicability of MOFs. MOFs porosity and functional sites are critical to the development of the sensor. Then, MOF biosensors for target cancer biomarkers detection have been discussed. In addition, the MOFs biosensors challenges and future direction are discussed to provide next-generation biosensors.

金属有机框架（MOF）是一种用于癌症生物标志物检测的重要多孔材料。它们富含永久孔隙率和可调孔径的独特特征，使其能够有效地用于生物传感。在这篇综述中，我们总结并研究了用于癌症生物标志物电化学检测的MOF材料。首先，讨论了对可调孔隙率和表面积的深入了解，以探索 MOF 的适用性。MOF 的孔隙率和功能位点对于传感器的开发至关重要。然后，讨论了用于目标癌症生物标志物检测的MOF生物传感器。此外，还讨论了 MOF 生物传感器的挑战和未来方向，以提供下一代生物传感器。