To obtain an overall enhancement on corrosion resistance, antimicrobial efficacies, and cytocompatibility of titanium-based implants, the multifunctional coatings in the forms of mono, double, and co-existence based on CuO and ZnO were innovatively designed by regulating the sputtering orders under magnetron sputtering. The results showed that ZnO and CuO were pure phases, CuO grains performed large and unevenly while ZnO grains were fine and homogeneous, such grains morphology features remerged on double-layered coatings. The surface roughness (R_q) of the monolayer to the double layer and then to the co-existing one was increased from 2.58 nm to 18 nm to 22.6 nm. All multifunctional coatings helped to lower the contact angle to a minimum of 18.82°, and enhanced the corrosion potential to a maximum of −0.261 V. The released ions, grains piercing, and ROS produced by p-n junctions co-played the bactericidal roles, which equipped ZnO/CuO composite coatings with bactericidal rates of 90.24%∼100% as directly contact with the target germs in 0.5 h. Owing to the strong metal–oxygen bonding and rough surface, all coatings supported the cell viabilities of 137.92%∼145.27% through 120 h co-culturing, MC3T3-E1 cells healthily proliferated and adhered on the surface. The double-layered coating, with ZnO as the bottom layer and CuO as the upper layer, exhibited better overall properties.

为了全面提高钛基植入物的耐腐蚀性、抗菌功效和细胞相容性，通过调节磁控管下的溅射顺序，创新设计了基于CuO和ZnO的单层、双层和共存形式的多功能涂层溅射。结果表明，ZnO和CuO均为纯相，CuO晶粒大且不均匀，ZnO晶粒细小且均匀，这种晶粒形貌特征在双层镀层上得以重现。表面粗糙度（R _q）从单层到双层，再到共存层，从2.58 nm增加到18 nm到22.6 nm。所有多功能涂层都有助于将接触角降至最低18.82°，并将腐蚀电位提高至最高-0.261 V。pn结释放的离子、晶粒刺穿和ROS共同发挥杀菌作用，配备ZnO/CuO复合涂层，直接接触目标病菌0.5 h杀菌率为90.24%∼100%。由于强金属-氧键合和粗糙的表面，所有涂层在共培养120小时后细胞活力保持在137.92%∼145.27%，MC3T3-E1细胞健康增殖并粘附在表面。以ZnO为底层、CuO为上层的双层涂层表现出更好的综合性能。