Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed that OMT has a wide range of beneficial pharmacological values, consisting of anticancer, antidiabetic, antivirus, and antiinflammtion, as well as the protective activities to the brain, liver, heart, lung, vascular, gastrointestinal, bone, kidney, and skin organs. Various in vitro and in vivo models of pharmacological actions were recorded in regard to the usage of alkaloidal OMT. Mechanisms underlying anticancer activity of this compound may have been possibly involved anti-proliferation, invasion, migration, angiogenesis, epithelial-mesenchymal transition of cells, autophagy, especially apoptotic cell deaths. OMT could reduce hyperglycemia and hyperlipemia in a high-fat diet and streptozotocin-stimulated diabetic mice by improving insulin secretion and sensitivity. OMT suppressed gastric ulcer via gastric inflammatory and oxidative inhibitions, and pro-apoptotic actions. It turns out that OMT is relatively safe for cell and animal experiments. In this study, we offer a systematic review of natural occurrence, pharmacological potentials, possible mechanisms of action, pharmacokinetics, and bioavailability. Clinical research with OMT is needed to extensively elucidate its health potential benefits

氧化苦参碱（Oxymatrine，OMT）被鉴定为喹里西啶生物碱，是从槐属药用植物中提取的主要苦参碱型生物碱之一。越来越多的研究表明，OMT 具有广泛的有益药理价值，包括抗癌、抗糖尿病、抗病毒和抗炎，以及对大脑、肝脏、心脏、肺、血管、胃肠道、骨骼、肾脏和神经系统的保护活性。皮肤器官。各种体外和体内记录了关于生物碱OMT使用的药理作用模型。该化合物的抗癌活性机制可能涉及抗增殖、侵袭、迁移、血管生成、细胞上皮间质转化、自噬，尤其是细胞凋亡。OMT 可以通过改善胰岛素分泌和敏感性来降低高脂肪饮食和链脲佐菌素刺激的糖尿病小鼠的高血糖和高脂血症。OMT抑制胃溃疡通过胃炎症和氧化抑制以及促凋亡作用。事实证明，OMT 对于细胞和动物实验来说是相对安全的。在这项研究中，我们对自然发生、药理学潜力、可能的作用机制、药代动力学和生物利用度进行了系统回顾。需要 OMT 的临床研究来广泛阐明其对健康的潜在益处