用于化学/化学动力学/光热联合癌症治疗的普鲁士蓝@铜掺杂磷酸锌纳米复合材料的设计合成,Journal of Materials Chemistry B

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用于化学/化学动力学/光热联合癌症治疗的普鲁士蓝@铜掺杂磷酸锌纳米复合材料的设计合成
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-06-08 , DOI: 10.1039/d3tb00342f
Xiaoxue Hu ₁ , Xiaoning Song ₁ , Yuan Yuan ₁ , Xintao Yao ₁ , Xiangjun Chen ₂ , Gang Li ₁ , Shengnan Li ₁

Affiliation

设计结合多种治疗方法的多功能纳米平台已成为一种创新的癌症治疗策略。提出了一种简单而明确的路线来开发集成三模式疗法（化学疗法、化学动力学疗法和光热疗法）的Cu ²⁺掺杂磷酸锌包覆普鲁士蓝纳米粒子（称为PB@Cu ²⁺ /ZnP NPs），以最大限度地发挥抗-肿瘤疗效。由于Cu ²⁺掺杂的ZnP壳中存在介孔结构，所获得的PB@Cu ²⁺ /ZnP NPs具有载药能力。此外，Cu ²⁺掺杂的ZnP壳可以响应弱酸性肿瘤微环境而逐渐降解，释放DOX和Cu ²⁺，其中释放的药物起到化疗剂的作用，并且Cu ²⁺可以与细胞内谷胱甘肽反应，实现Cu介导的芬顿样反应，用于化学动力学治疗。此外，在激光照射下，PB的光热转化所产生的热量可用于光热治疗，增强有毒的˙OH的产生和DOX的释放量，进一步促进化疗和化学动力学治疗，实现联合治疗。重要的是，PB@Cu ²⁺ /ZnP NPs通过化学/化学动力学/光热疗法的协调作用有效限制肿瘤的生长，并且在小鼠中没有发现明显的系统毒性。总的来说，PB@Cu ²⁺/ZnP NPs 可以作为肿瘤多模式治疗的前瞻性治疗纳米平台。

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Designed synthesis of prussian blue@Cu-doped zinc phosphate nanocomposites for chemo/chemodynamic/photothermal combined cancer therapy

Designing a multifunctional nanoplatform that combines multiple treatments has emerged as an innovative cancer treatment strategy. A simple and clear route is put forward to develop Cu²⁺-doped zinc phosphate coated prussian blue nanoparticles (designated as PB@Cu²⁺/ZnP NPs) integrating tri-modal therapy (chemo, chemodynamic and photothermal therapy) for maximizing anti-tumor efficacy. The obtained PB@Cu²⁺/ZnP NPs possess drug loading capacity due to the mesoporous structure present in the Cu²⁺-doped ZnP shell. In addition, the Cu²⁺-doped ZnP shell can gradually degrade in response to the mildly acidic tumor microenvironment to release DOX and Cu²⁺, where the released drug plays the role of chemotherapy agent and the Cu²⁺ can react with intracellular glutathione to achieve a Cu-mediated Fenton-like reaction for chemodynamic therapy. Moreover, under laser irradiation, the heat garnered by the photothermal conversion of PB can be applied for photothermal therapy and enhance the generation of toxic ˙OH as well as the amount of DOX released, further boosting chemo- and chemodynamic therapy to realize a combined therapy. Importantly, the PB@Cu²⁺/ZnP NPs effectively limit the growth of tumors via the coordinated action of chemo/chemodynamic/photothermal therapy and no noticeable systematic toxicity can be found in mice. Taken together, the PB@Cu²⁺/ZnP NPs can act as a prospective therapeutic nanoplatform for multi-modal therapy of tumors.

更新日期：2023-06-08

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