Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis,Journal of the American Chemical Society

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Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2023-06-07 , DOI: 10.1021/jacs.3c02669
Yanling You _{1,

2} , Ya-Xuan Zhu ₃ , Junjie Jiang ₄ , Zhixin Chen _{1,

2} , Chenyao Wu ₅ , Zhimin Zhang _{1,

2} , Han Lin _{1,

3} , Jianlin Shi _{1,

2,

3}

Affiliation

Iodine, as a typical haloid element in group VIIA, has been extensively applied as antiseptics clinically, thanks to its effective and wide-spectrum antimicrobial activity against bacteria, fungi, and viruses. Nevertheless, current iodic sterilizing agents are still limited to topical applications such as instrument sterilization and treatments of skin or mucous membrane infection due to its unsatisfactory stability and biocompatibility. Here, we propose an emerging two-dimensional iodine nanomaterial (noted as iodinene) for the treatment of infection diseases in vivo. Iodinene nanosheets were fabricated by a facile and environmentally friendly approach via sonication-assisted liquid exfoliation, which present an intriguing layered structure and negligible toxicity. The as-synthesized iodinene would experience an in situ allotropic transformation spontaneously to release active HIO and I₂ molecules by reacting with H₂O₂ in the infectious microenvironment. By the in situ production of active HIO and I₂ molecules via allotropic transformation, iodinene presents enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In vivo outcome demonstrates the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia. This study thus offers an alternative to conventional sterilizing agents against hard-to-treat bacterial infections.

中文翻译：

碘烯纳米片到碘分子的同素异形转化用于抗菌

碘作为第VIIA族的典型卤族元素，因其对细菌、真菌和病毒具有有效、广谱的抗菌活性，作为防腐剂在临床上得到广泛应用。然而，目前的碘消毒剂由于其稳定性和生物相容性不理想，仍仅限于局部应用，如器械消毒和皮肤或粘膜感染的治疗。在这里，我们提出了一种新兴的二维碘纳米材料（称为碘烯）用于治疗体内感染性疾病。碘烯纳米片是通过超声辅助液体剥离以简便且环保的方法制备的，其呈现出有趣的层状结构和可忽略不计的毒性。合成的碘烯会自发地发生原位同素异形转变，通过与感染性微环境中的H ₂ O ₂反应释放活性HIO和I ₂分子。通过同素异形转化原位产生活性 HIO 和 I ₂分子，碘烯对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌具有增强的抗菌功效。体内结果表明碘在治疗细菌性伤口感染和肺炎方面具有理想的抗菌功效。因此，这项研究为对抗难以治疗的细菌感染提供了传统灭菌剂的替代方案。

更新日期：2023-06-07

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