Selective [3 + 2] cycloaddition reaction of isothiazol-3(2h)-ones with in situ formed azomethine ylide to thiazolidines and oxazolidines,Journal of Heterocyclic Chemistry

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Selective [3 + 2] cycloaddition reaction of isothiazol-3(2h)-ones with in situ formed azomethine ylide to thiazolidines and oxazolidines
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2023-06-05 , DOI: 10.1002/jhet.4668
Wen Bin Jin _{1,

2} , Zhen Wang _{2,

3} , Wei Yang ₁ , Die Zhang ₁ , Jin Hua Ning ₁ , Jing Ke ₁ , An Guo Hou ₁ , Lin Yun Chen ₁ , Yun Shu Ma ₁

Affiliation

Novel selective [3 + 2] cycloaddition reactions between in situ formed nonstabilized azomethine ylide generated from N-benzyl-1-methoxy-N-((trimethylsilyl)methyl)methanamine enabled by Lewis acids and bioactive molecules isothiazol-3(2H)-ones have been developed. The reaction selectively afforded novel thiazolidines or cyclo-fused oxazolidinones depending on Lewis acid catalyst system of reaction used.

中文翻译：

异噻唑-3(2h)-酮与原位形成的偶氮甲碱叶立德选择性[3 + 2]环加成反应生成噻唑烷和恶唑烷

由路易斯酸引发的N-苄基-1-甲氧基-N-((三甲基硅基)甲基)甲胺原位形成的不稳定偶氮甲碱叶立德与生物活性分子异噻唑-3(2H)-酮之间的新型选择性[3 + 2]环加成反应已经开发了。该反应根据所用的路易斯酸催化剂体系选择性地提供新型噻唑烷或环稠合恶唑烷酮。

更新日期：2023-06-05

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