Inspired by Nature: Isostere Concepts in Plant Hormone Chemistry,Journal of Agricultural and Food Chemistry

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Inspired by Nature: Isostere Concepts in Plant Hormone Chemistry
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-06-05 , DOI: 10.1021/acs.jafc.3c01809
Jens Frackenpohl ₁ , Steven A G Abel ₁ , Neanne Alnafta ₁ , David M Barber ₁ , Guido Bojack ₁ , Nicola Z Brant ₁ , Hendrik Helmke ₁ , Rebecca L Mattison ₁

Affiliation

Chemical concepts such as isosteres and scaffold hopping have proven to be powerful tools in agrochemical innovation processes. They offer opportunities to modify known molecular lead structures with the aim to improve a range of parameters, including biological efficacy and spectrum, physicochemical properties, stability, and toxicity. While recent biochemical insights into plant-specific receptors and signaling pathways trigger the discovery of the first lead structures, the disclosure of such a new chemical structure sparks a broad range of synthesis activities giving rise to diverse chemical innovation and often a considerable boost in biological activity. Herein, recent examples of isostere concepts in plant-hormone chemistry will be discussed, outlining how synthetic creativity can broaden the scope of natural product chemistry and giving rise to new opportunities in research fields such as abiotic stress tolerance and growth promotion.

中文翻译：

受大自然启发：植物激素化学中的等排概念

等排体和支架跳跃等化学概念已被证明是农用化学品创新过程中的强大工具。它们提供了修改已知分子先导结构的机会，旨在改善一系列参数，包括生物功效和谱、理化性质、稳定性和毒性。虽然最近对植物特异性受体和信号传导途径的生化见解触发了第一个先导结构的发现，但这种新化学结构的披露引发了广泛的合成活动，从而引发了多样化的化学创新，并且通常大大提高了生物活性。在此，将讨论植物激素化学中等排体概念的最新例子，概述合成创造力如何扩大天然产物化学的范围，并在非生物胁迫耐受性和生长促进等研究领域带来新的机遇。

更新日期：2023-06-05

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