Triple ipso-defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols: access to fluoroalkylated orthoesters via C(sp3)–F bond cleavage,Chemical Communications

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Triple ipso-defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols: access to fluoroalkylated orthoesters via C(sp3)–F bond cleavage
Chemical Communications ( IF 4.3 ) Pub Date : 2023-06-05 , DOI: 10.1039/d3cc01760e
Jia Nie ₁ , Huanfeng Jiang ₁ , Chuanle Zhu _{1,

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Affiliation

The triple ipso-defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols by C(sp³)–F bond cleavage is reported, delivering various fluoroalkylated orthoesters in high yields. This reaction is transition-metal free and gram-scalable, features mild reaction conditions, and tolerates diverse functional groups.

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