Engineering the Coacervate Microdroplet Interface via Polyelectrolyte and Surfactant Complexation,ACS Applied Materials & Interfaces

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Engineering the Coacervate Microdroplet Interface via Polyelectrolyte and Surfactant Complexation
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-06-05 , DOI: 10.1021/acsami.3c00727
Chengying Yin ₁ , Zi Lin ₂ , Xingyu Jiang ₁ , Nicolas Martin ₂ , Liangfei Tian _{1,

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Affiliation

Complex coacervate microdroplets, which are formed via spontaneous liquid–liquid phase separation by mixing two oppositely charged polyelectrolytes in water, have emerged as a new paradigm in the fields of origin of life, membraneless subcellular compartmentalization, bioreactors, and drug delivery. However, how to further improve its stability and enhance its selectivity in one particular coacervate system remains a challenge. By generating a membrane-like layer at the surface of coacervate microdroplets via electrostatic interactions between oppositely charged surfactants and polyelectrolytes, we here achieve tunable permeability and enhanced stability of the coacervates at the same time. Depending on the surfactants used, membrane-like layer-coated coacervate microdroplets exhibit different selectivity over solute sequestration and can promote or inhibit DNA hybridization. Our approach provides a practical tool to engineer functional bioinspired microcompartments with potential applications in the fields of controlled drug release and microreactor technology.

中文翻译：

通过聚电解质和表面活性剂络合设计凝聚层微滴界面

通过在水中混合两种带相反电荷的聚电解质，通过自发液-液相分离形成复杂的凝聚层微滴，已成为生命起源、无膜亚细胞区室化、生物反应器和药物输送领域的新范例。然而，如何进一步提高其稳定性并增强其在特定凝聚层体系中的选择性仍然是一个挑战。通过带相反电荷的表面活性剂和聚电解质之间的静电相互作用在凝聚层微滴表面生成膜状层，我们在这里同时实现了可调渗透性和增强的凝聚层稳定性。根据所用的表面活性剂，膜状层包被的凝聚层微滴对溶质螯合表现出不同的选择性，可以促进或抑制 DNA 杂交。我们的方法提供了一种实用工具来设计功能性仿生微隔室，在受控药物释放和微反应器技术领域具有潜在应用。

更新日期：2023-06-05

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