Excess levels of glucose in the blood can result in various complications such as heart disease, kidney failure, and blindness. Therefore, it is crucial to quantitatively measure blood glucose levels. At room temperature, by employing coordinating etching and precipitating process, and sulfidation reaction, we have developed a range of glucose sensing materials, including hollow Ni(OH)₂@CuS (H-Ni(OH)₂@CuS), Cu₂O cubes, hollow CuS (H-CuS), hollow Ni(OH)₂ (H-Ni(OH)₂), and core-shell Cu₂O@Ni(OH)₂. Electrochemical tests showed that H-Ni(OH)₂@CuS has the highest glucose sensing sensitivity (2738.57 μA mM^-1 cm^-2) and the widest linear range (0.01 - 6.64 mM), with a detection limit of 3.3 μM (LOD= 3σ/S) compared with those of other materials. The superior electrochemical performance of H-Ni(OH)₂@CuS can be attributed to the unique advantages of the hollow structure and the synergistic effect among multi-components in the heterojunction. The H-Ni(OH)₂@CuS based sensor also demonstrates reliable reproducibility, long-term stability, and excellent anti-interference capability. Furthermore, it shows acceptable accuracy in detecting actual human serum samples, indicating its important practical application value.

血液中葡萄糖含量过高会导致各种并发症，例如心脏病、肾衰竭和失明。因此，定量测量血糖水平至关重要。在室温下，通过采用协调蚀刻和沉淀工艺以及硫化反应，我们开发了一系列葡萄糖传感材料，包括空心 Ni(OH) ₂ @CuS (H-Ni(OH) ₂ @CuS)、Cu ₂ O立方体，空心CuS（H-CuS），空心Ni（OH）₂（H-Ni（OH）₂）和核壳Cu ₂ O@Ni（OH）₂。电化学测试表明，H-Ni(OH) ₂ @CuS具有最高的葡萄糖传感灵敏度（2738.57 μA mM ^-1 cm^-2 ) 和最宽的线性范围 (0.01 - 6.64 mM)，与其他材料相比，检出限为 3.3 μM (LOD= 3σ/S)。_{H-Ni(OH) 2} @CuS优异的电化学性能可归因于中空结构的独特优势和异质结中多组分之间的协同效应。基于H-Ni(OH) ₂ @CuS的传感器还表现出可靠的重现性、长期稳定性和出色的抗干扰能力。此外，它在检测实际人血清样本时表现出可接受的准确度，表明其具有重要的实际应用价值。