Inadequate Hydration Status of Test Subjects Can Affect Bioavailability Studies,ACS Pharmacology & Translational Science

当前位置： X-MOL 学术 › ACS Pharmacol. Transl. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Inadequate Hydration Status of Test Subjects Can Affect Bioavailability Studies
ACS Pharmacology & Translational Science ( IF 4.9 ) Pub Date : 2023-06-01 , DOI: 10.1021/acsptsci.3c00089
Reza Rastmanesh _{1,

2,

3}

Affiliation

This Viewpoint identifies some of the pitfalls in the bioavailability of water-soluble drugs and introduces a novel bias we term the “hypohydration bias”. We suggest that future bioavailability studies take some important neglected confounding factors into account, and we propose that, to avoid such a bias, some relevant variables such as serum and urine osmolality, dry weight adjustment, fluid balance, semi-nude body mass, saliva osmolality, saliva total protein concentration, and urine specific gravity should be controlled to increase the precision of the bioavailability measurements. We suggest that a new definition of hydration status is needed, and that systematic protocols of bioavailability studies should be revisited.

中文翻译：

测试对象的水合状态不足会影响生物利用度研究

该观点指出了水溶性药物生物利用度方面的一些缺陷，并引入了一种新的偏差，我们称之为“缺水偏差”。我们建议未来的生物利用度研究考虑一些重要的被忽视的混杂因素，并且我们建议，为了避免这种偏差，一些相关变量，如血清和尿液渗透压、干重调整、液体平衡、半裸体重、唾液应控制渗透压、唾液总蛋白浓度和尿比重，以提高生物利用度测量的精度。我们建议需要对水合状态进行新的定义，并且应该重新审视生物利用度研究的系统方案。

更新日期：2023-06-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文