The healing process of infected skin lesions is often delayed by many factors including bacterial infection, excessive accumulation of wound exudate, poor local perfusion, and low cell recruitment. Development of wound dressing for efficient wound management and promotion of wound healing is a great challenge. Herein, we constructed a Janus nanofiber dressing with the comprehensive capacities of bacterial killing, piezoelectrical stimulation for promoting fibroblast migration, and wound exudate removal via unidirectional liquid delivery. The rationally designed Janus nanofibrous dressing with ultrathin, flexible, breathable, and piezoelectric characteristics is fabricated via the facile layer-by-layer electrostatic spinning technology. The hydrophilic layer of the dressing is composed of randomly arranged polycaprolactone/gelatin (PCL/Gel) nanofibers, while the hydrophobic layer consists of well-aligned Ag nanoparticles (Ag NPs)-doped piezoelectric polyvinylidene fluoride (PVDF/Ag) nanofibers. The in vitro and in vivo experimental results demonstrate that the Janus dressing can not only drain excess wound exudate out of the wound unidirectionally and kill local bacteria, but also generate dynamic piezopotential under normal body motions to promote fibroblast proliferation and migration, collagen deposition, angiogenesis, and re-epithelialization, which accelerates rapid wound healing on mice. The smart Janus dressing will provide a new approach for acceleration of wound healing and wound management.

感染性皮损的愈合过程常因细菌感染、创面渗液过多积聚、局部灌注不良、细胞募集不足等多种因素而延缓。开发用于有效伤口管理和促进伤口愈合的伤口敷料是一项巨大的挑战。在此，我们构建了一种 Janus 纳米纤维敷料，具有杀菌、促进成纤维细胞迁移的压电刺激和通过单向液体输送去除伤口渗出液的综合能力。合理设计的具有超薄、柔韧、透气、压电特性的Janus纳米纤维敷料是通过简便的逐层静电纺丝技术。敷料的亲水层由随机排列的聚己内酯/明胶 (PCL/Gel) 纳米纤维组成，而疏水层由排列良好的银纳米粒子 (Ag NPs) 掺杂的压电聚偏氟乙烯 (PVDF/Ag) 纳米纤维组成。体外和体内_实验结果表明，Janus 敷料不仅可以将多余的伤口渗出物单向引流出伤口，杀死局部细菌，而且在正常身体运动下产生动态压电，促进成纤维细胞增殖和迁移、胶原沉积、血管生成和再上皮化，加速小鼠伤口的快速愈合。智能 Janus 敷料将为加速伤口愈合和伤口管理提供一种新方法。