<br>人类肠道细胞图谱路线图,Nature Reviews Gastroenterology & Hepatology

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人类肠道细胞图谱路线图
Nature Reviews Gastroenterology & Hepatology ( IF 45.9 ) Pub Date : 2023-05-31 , DOI: 10.1038/s41575-023-00784-1
Matthias Zilbauer _{1,

2,

3} , Kylie R James _{4,

5} , Mandeep Kaur ₆ , Sebastian Pott ₇ , Zhixin Li ₈ , Albert Burger ₉ , Jay R Thiagarajah ₁₀ , Joseph Burclaff _{11,

12} , Frode L Jahnsen ₁₃ , Francesca Perrone _{1,

2} , Alexander D Ross _{1,

2,

14} , Gianluca Matteoli ₁₅ , Nathalie Stakenborg ₁₅ , Tomohisa Sujino ₁₆ , Andreas Moor ₁₇ , Raquel Bartolome-Casado _{13,

18} , Espen S Bækkevold ₁₃ , Ran Zhou ₇ , Bingqing Xie ₁₉ , Ken S Lau ₂₀ , Shahida Din ₂₁ , Scott T Magness _{11,

12} , Qiuming Yao ₂₂ , Semir Beyaz ₂₃ , Mark Arends ₂₄ , Alexandre Denadai-Souza ₂₅ , Lori A Coburn _{26,

27} , Jellert T Gaublomme ₂₈ , Richard Baldock ₂₉ , Irene Papatheodorou ₃₀ , Jose Ordovas-Montanes ₁₀ , Guy Boeckxstaens ₁₅ , Anna Hupalowska ₃₁ , Sarah A Teichmann _{18,

32} , Aviv Regev _{31,

33} , Ramnik J Xavier ₃₄ , Alison Simmons ₃₅ , Michael P Snyder ₃₆ , Keith T Wilson _{26,

27} , ,

Affiliation

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
University Department of Paediatrics, University of Cambridge, Cambridge, UK.
Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Cambridge, UK.
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia.
School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa.
Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Computer Science, Heriot-watt University, Edinburgh, UK.
Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University', Chapel Hill, NC, USA.
Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway.
University Department of Medical Genetics, University of Cambridge, Cambridge, UK.
Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Center for the Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan.
Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
Wellcome Sanger Institute, Hinxton, UK.
Department of Medicine, University of Chicago, Chicago, IL, USA.
Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Edinburgh IBD Unit, Western General Hospital, NHS Lothian, Edinburgh, UK.
Department of Computer Science and Engineering, University of Nebraska Lincoln, Lincoln, NE, USA.
Cold Spring Harbour Laboratory, Cold Spring Harbour, New York, NY, USA.
Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Cancer and Genetics, University of Edinburgh, Edinburgh, UK.
Laboratory of Mucosal Biology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.
Vanderbilt University Medical Center, Nashville, TN, USA.
Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.
Department of Biological Sciences, Columbia University, New York, NY, USA.
University of Edinburgh, Edinburgh, UK.
European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Genome Campus, Hinxton, UK.
Genentech, San Francisco, CA, USA.
Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK.
Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Broad Institute and Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Stanford University School of Medicine, Stanford, CA, USA.

在过去几年中，使用各种单细胞分析方法研究人类胃肠道的研究数量大幅增加。尽管这一增长为第一个全面的人类肠道细胞图谱（HGCA）的生成提供了独特的机会，但未来仍然存在一系列重大挑战。最重要的是，最终的成功将在很大程度上取决于结构化和协调的方法，该方法需要协调大量研究小组的全球努力。在本路线图中，我们代表人类细胞图谱肠道生物网络讨论了 HGCA 生成的全面前瞻性方向。基于全球专家的共识，我们通过总结现有数据集并突出覆盖范围有限的解剖区域和/或组织，概述了第一个完整 HGCA 的主要要求。我们为未来的研究提供建议，并讨论关键方法以及将健康肠道图谱与相关疾病和肠道类器官相结合的重要性。重要的是，我们批判性地概述了可用的计算工具，并提供了克服关键挑战的建议。

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更新日期：2023-06-01

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