Crosstalk between Adult Hippocampal Neurogenesis and Its Role in Alzheimer’s Disease,ACS Chemical Neuroscience

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Crosstalk between Adult Hippocampal Neurogenesis and Its Role in Alzheimer’s Disease
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2023-06-01 , DOI: 10.1021/acschemneuro.3c00119
Virendra Tiwari _{1,

2} , Akanksha Mishra _{1,

3} , Sonu Singh _{1,

4} , Shubha Shukla _{1,

2}

Affiliation

The functional and developmental unit of neurogenesis is neural stem cells (NSCs). These NSCs have self-renewal capacity and produce new neurons throughout life in different neurogenic niche. Neurogenesis in adult brain is associated with synaptic plasticity, learning, and memory in dentate gyrus (DG) of hippocampus and olfactory bulb. Remarkably, weakened neurogenesis has been viewed before the onset of different pathological hallmarks of neurological disorders. In this review, we have provided evidence which implicates impaired neurogenesis as a culprit in age associated neurological disorders with greater emphasis on Alzheimer’s disease (AD). Moreover, an insight about the molecular and cellular regulation linked with altered neurogenesis in young and aging brain has also been discussed. This review further summarizes the therapeutic strategies for targeting the manipulation of the neural stem cell pool and factors affecting the pool involved in AD.

中文翻译：

成人海马神经发生之间的串扰及其在阿尔茨海默病中的作用

神经发生的功能和发育单位是神经干细胞（NSC）。这些神经干细胞具有自我更新能力，并在整个生命过程中在不同的神经源性生态位中产生新的神经元。成人大脑的神经发生与海马齿状回 (DG) 和嗅球的突触可塑性、学习和记忆有关。值得注意的是，在神经系统疾病的不同病理特征出现之前就已经观察到神经发生减弱。在这篇综述中，我们提供的证据表明，神经发生受损是与年龄相关的神经系统疾病的罪魁祸首，尤其是阿尔茨海默病 (AD)。此外，还讨论了与年轻和衰老大脑神经发生改变相关的分子和细胞调节的见解。

更新日期：2023-06-01

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