Serum HMGB1 levels are independently associated with glucose clamp-derived measures of insulin resistance in women with PCOS,Journal of Endocrinological Investigation

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Serum HMGB1 levels are independently associated with glucose clamp-derived measures of insulin resistance in women with PCOS
Journal of Endocrinological Investigation ( IF 3.9 ) Pub Date : 2023-05-31 , DOI: 10.1007/s40618-023-02119-y
P Moghetti ₁ , C Catellani _{2,

3} , C Sartori ₂ , M Migazzi ₁ , F Cirillo ₂ , M Villani ₁ , V Buia ₂ , B Righi ₂ , M Dauriz _{1,

4} , T Fiers ₅ , F Tosi ₁ , M E Street _{2,

6,

7}

Affiliation

Purpose

PCOS is associated with low grade inflammation which could play a role in insulin resistance and ovarian dysfunction. Preliminary findings suggested that serum levels of HMGB1, a cytokine involved in inflammation, might be altered in women with PCOS. Primary aim of this study was to assess whether HMGB1 serum concentrations are associated with PCOS and with the state of insulin resistance of these women.

Methods

Sixty women with PCOS, selected to have a similar proportion of subjects with altered or normal insulin sensitivity, and 29 healthy controls were studied. Serum HMGB1 levels were compared in subgroups of PCOS women and controls. In PCOS women, insulin sensitivity was assessed by the glucose clamp technique and HMGB1 was measured at baseline and after acute hyperinsulinemia.

Results

HMGB1 levels were similar in women with PCOS and controls and no elements used for diagnosing PCOS were associated with serum HMGB1. However, HMGB1 concentrations were higher in insulin-resistant vs insulin-sensitive PCOS women (p = 0.017), and inversely associated with insulin-induced total and non-oxidative glucose metabolism. In both subgroups of PCOS women, serum HMBG1 levels significantly increased after acute hyperinsulinemia.

Conclusions

These data suggest that HMGB1 levels are not associated with PCOS per se, but with insulin resistance. Further research should establish the underlying nature of this relationship, and whether this protein might play a role in the metabolic complications of PCOS.

中文翻译：

血清 HMGB1 水平与 PCOS 女性胰岛素抵抗的葡萄糖钳衍生测量值独立相关

目的

多囊卵巢综合症与低度炎症有关，可能在胰岛素抵抗和卵巢功能障碍中发挥作用。初步研究结果表明，患有 PCOS 的女性血清中 HMGB1（一种与炎症有关的细胞因子）水平可能会发生变化。本研究的主要目的是评估 HMGB1 血清浓度是否与 PCOS 以及这些女性的胰岛素抵抗状态相关。

方法

研究人员选择了 60 名患有 PCOS 的女性，其中选择了相似比例的胰岛素敏感性改变或正常的受试者，以及 29 名健康对照者。对 PCOS 女性亚组和对照组的血清 HMGB1 水平进行了比较。在 PCOS 女性中，通过葡萄糖钳夹技术评估胰岛素敏感性，并在基线时和急性高胰岛素血症后测量 HMGB1。

结果

患有 PCOS 的女性和对照组的 HMGB1 水平相似，并且用于诊断 PCOS 的元素与血清 HMGB1 无关。然而，与胰岛素敏感的 PCOS 女性相比，胰岛素抵抗女性的 HMGB1 浓度较高 ( p = 0.017)，并且与胰岛素诱导的总葡萄糖代谢和非氧化葡萄糖代谢呈负相关。在 PCOS 女性的两个亚组中，急性高胰岛素血症后血清 HMBG1 水平均显着升高。