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化合物 42 通过靶向 RIPK3 介导的坏死性凋亡减轻急性肾损伤
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2023-05-30 , DOI: 10.1111/bph.16152 Xiao-Yan He 1 , Fang Wang 1, 2 , Xiao-Guo Suo 1 , Ming-Zhen Gu 1 , Jia-Nan Wang 1 , Chuan-Hui Xu 1 , Yu-Hang Dong 1 , Yuan He 1 , Yao Zhang 1 , Ming-Lu Ji 1 , Ying Chen 1 , Meng-Meng Zhang 1 , Yin-Guang Fan 3 , Jia-Gen Wen 1 , Juan Jin 4 , Jie Wang 1 , Jun Li 1 , Chun-Lin Zhuang 5 , Ming-Ming Liu 1 , Xiao-Ming Meng 1
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2023-05-30 , DOI: 10.1111/bph.16152 Xiao-Yan He 1 , Fang Wang 1, 2 , Xiao-Guo Suo 1 , Ming-Zhen Gu 1 , Jia-Nan Wang 1 , Chuan-Hui Xu 1 , Yu-Hang Dong 1 , Yuan He 1 , Yao Zhang 1 , Ming-Lu Ji 1 , Ying Chen 1 , Meng-Meng Zhang 1 , Yin-Guang Fan 3 , Jia-Gen Wen 1 , Juan Jin 4 , Jie Wang 1 , Jun Li 1 , Chun-Lin Zhuang 5 , Ming-Ming Liu 1 , Xiao-Ming Meng 1
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坏死性凋亡在急性肾损伤中发挥重要作用，由受体相互作用蛋白激酶 1 (RIPK1)、受体相互作用蛋白激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL) 介导。化合物 42 (Cpd-42) 是一种新型 RIPK3 抑制剂，可减轻全身炎症反应。本研究旨在探讨 Cpd-42 是否对急性肾损伤具有保护作用并揭示其潜在机制。
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更新日期：2023-05-30
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