The evaluation of potato starch plasticization efficiency with two deep eutectic solvents (DESs), based on choline chloride (CC) and glycerol (G) or urea (U) has been performed. The optical microscopy allowed to observe that both DES exhibited some solubility towards starch, however, the solvent power of CCU was significantly higher than CCG. The XRD result revealed that both tested systems showed the ability to penetrate the starch crystal regions. Moreover, both DESs could form stable hydrogen bonds with hydroxylic groups of the polysaccharide. The viscosity of tested systems depended on starch content (decreased with DES amount), and temperature. The thermal stability of starch material decreased with DES content. The type of DES strongly affected gelatinization temperature (rheology curves), i.e. in CCU it occurred at the temperature below 90 °C, in comparison to CCG - above 110 °C. The plasticization efficiency was tested using the modulated DSC technique. The CCG system exhibited higher plasticizing efficiency, as its lower dosage allowed for a more significant T_g reduction than observed for the system containing CCU. Thus, it could be concluded that although CCG was a poor solvent, was a good plasticizer.