Cyclohexanone oxime, an important nylon-6 precursor, is conventionally synthesized through cyclohexanone-hydroxylamine (NH₂OH) and cyclohexanone ammoxidation methodologies. These strategies require complicated procedures, high temperatures, noble metal catalysts, and toxic SO₂ or H₂O₂ usage. Here, we report a one-step electrochemical strategy to synthesize cyclohexanone oxime from nitrite (NO₂⁻) and cyclohexanone under ambient conditions using a low-cost Cu-S catalyst, avoiding complex procedures, noble metal catalysts and H₂SO₄/H₂O₂ usage. This strategy produces 92% yield and 99% selectivity of cyclohexanone oxime, comparable to the industrial route. The reaction undergoes a NO₂⁻ → NH₂OH→oxime reaction pathway. This electrocatalytic strategy is suitable for the production of other oximes, highlighting the methodology universality. The amplified electrolysis experiment and techno-economic analysis confirm its practical potential. This study opens a mild, economical, and sustainable way for the alternative production of cyclohexanone oxime.

_{环己酮肟是一种重要的尼龙 6 前体，通常通过环己酮-羟胺 (NH 2} OH) 和环己酮氨氧化方法合成。这些策略需要复杂的程序、高温、贵金属催化剂和有毒的 SO ₂或 H ₂ O ₂使用。在这里，我们报告了一种在环境条件下使用低成本 Cu-S 催化剂从亚硝酸盐 (NO ₂ ^- ) 和环己酮合成环己酮肟的一步电化学策略，避免了复杂的程序、贵金属催化剂和 H ₂ SO ₄ /H ₂氧₂用法。该策略产生92%的产率和99%的环己酮肟选择性，与工业路线相当。该反应经历了NO ₂ ^-  → NH ₂ OH→ 肟反应途径。这种电催化策略适用于其他肟的生产，突出了方法学的普适性。放大电解实验和技术经济分析证实了其实用潜力。该研究为环己酮肟的替代生产开辟了一条温和、经济、可持续的途径。