Skeletal Editing of (Hetero)Arenes Using Carbenes,Chemistry - A European Journal

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Skeletal Editing of (Hetero)Arenes Using Carbenes
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2023-05-25 , DOI: 10.1002/chem.202301227
Zhaohong Liu ₁ , Paramasivam Sivaguru ₁ , Yongquan Ning ₁ , Yong Wu ₁ , Xihe Bi _{1,

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Affiliation

This review summarizes the state-of-the-art developments in the skeletal editing of (hetero)arenes using carbenes, with an emphasis on the scope, reactivity, selectivity, and general mechanistic considerations. The impressive breadth of application of this strategy in both drug discovery and total synthesis is also discussed. Existing challenges and perspectives on future research directions to further understanding and new reaction developments are outlined.

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