Self-Immolative Amphiphilic Poly(ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Self-Immolative Amphiphilic Poly(ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-05-26 , DOI: 10.1002/anie.202303829
Jie Xu ₁ , Jiajia Tan ₁ , Chengzhou Song ₁ , Guoying Zhang ₁ , Xianglong Hu _{1,

2,

3} , Shiyong Liu ₁

Affiliation

Self-immolative amphiphilic poly(ferrocenes) are fabricated with self-immolative backbone, aminoferrocene (AFc) side chains, and end-capping poly(ethylene glycol) monomethyl ether. Upon acidic milieu-triggered head-to-tail degradation, rational GSH depletion and reactive oxygen species burst is observed to amplify the oxidative stress for efficient tumor inhibition. This work provides a promising drug-free polymer strategy for precision medicine.

中文翻译：