The broad spectrum of biological activity of 2,6-naphthyridine, one of the six structural isomers of pyridopyridine, is the main reason for the development of new compounds containing this scaffold. This review paper aims to present various methods for obtaining 2,6-naphthyridine analogues and their biological activity, which have been reported in the scientific literature. Compounds containing the 2,6-naphthyridine moiety can be isolated from plants or obtained synthetically from various substrates: pyridine derivatives, other heterocyclic derivatives, or acyclic compounds. Biological investigations have shown that these compounds exhibit various biological activity; among others, they have an effect on the central nervous system or anticancer or antimicrobial activity.

中文翻译：

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2,6-萘啶衍生物的合成和生物活性：小综述

2,6-萘啶（吡啶并吡啶的六种结构异构体之一）的广谱生物活性是开发含有该支架的新化合物的主要原因。本综述旨在介绍科学文献中报道的各种获得 2,6-萘啶类似物的方法及其生物活性。含有2,6-萘啶部分的化合物可以从植物中分离或从各种底物合成获得：吡啶衍生物、其他杂环衍生物或无环化合物。生物学研究表明这些化合物表现出多种生物活性；其中，它们对中枢神经系统或抗癌或抗菌活性有影响。