用于连续监测汗液中乳酸的气泡不敏感微流控乳酸生物传感器,ACS Sensors

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用于连续监测汗液中乳酸的气泡不敏感微流控乳酸生物传感器
ACS Sensors ( IF 8.2 ) Pub Date : 2023-05-22 , DOI: 10.1021/acssensors.3c00490
Isao Shitanda _{1,

2} , Yuro Ozone ₁ , Yuki Morishita ₃ , Hiroyuki Matsui ₄ , Noya Loew ₁ , Masahiro Motosuke _{2,

3} , Takahiro Mukaimoto _{2,

5} , Momoko Kobayashi ₆ , Taketo Mitsuhara ₇ , Yamato Sugita ₇ , Kensuke Matsuo ₇ , Shinya Yanagita _{2,

5} , Tatsunori Suzuki ₆ , Tsutomu Mikawa ₈ , Hikari Watanabe ₁ , Masayuki Itagaki _{1,

2}

Affiliation

本研究旨在开发一种带有微通道的乳酸传感器，克服气泡干扰汗液中乳酸水平测量的问题，并评估其连续监测汗液中乳酸的潜力。为了实现乳酸的连续监测，使用微通道从乳酸传感器的电极供应和排出汗液。随后开发了一种带有微通道的乳酸传感器，该微通道具有专门设计用于捕获气泡并防止它们接触电极的区域。该传感器由一个人在运动时进行评估，以测试其监测汗液中乳酸的有效性及其与血乳酸水平的相关性。此外，本研究中带有微通道的乳酸传感器可以长时间佩戴在身上，有望用于汗液中乳酸的连续监测。开发的带有微通道的乳酸传感器有效防止气泡干扰汗液中乳酸水平的测量。该传感器显示出 1 至 50 mM 范围内的浓度相关性，并证明了汗液和血液中乳酸之间的相关性。此外，本研究中带有微通道的乳酸传感器可以长时间佩戴在身上，预计可用于连续监测汗液中的乳酸，特别是在医学和体育领域。

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Air-Bubble-Insensitive Microfluidic Lactate Biosensor for Continuous Monitoring of Lactate in Sweat

This study aimed to develop a lactate sensor with a microchannel that overcomes the issue of air bubbles interfering with the measurement of lactate levels in sweat and to evaluate its potential for continuous monitoring of lactate in sweat. To achieve continuous monitoring of lactate, a microchannel was used to supply and drain sweat from the electrodes of the lactate sensor. A lactate sensor was then developed with a microchannel that has an area specifically designed to trap air bubbles and prevent them from contacting the electrode. The sensor was evaluated by a person while exercising to test its effectiveness in monitoring lactate in sweat and its correlation with blood lactate levels. Furthermore, the lactate sensor with a microchannel in this study can be worn on the body for a long time and is expected to be used for the continuous monitoring of lactate in sweat. The developed lactate sensor with a microchannel effectively prevented air bubbles from interfering with the measurement of lactate levels in sweat. The sensor showed a concentration correlation ranging from 1 to 50 mM and demonstrated a correlation between lactate in sweat and blood. Additionally, the lactate sensor with a microchannel in this study can be worn on the body for an extended period and is expected to be useful for the continuous monitoring of lactate in sweat, particularly in the fields of medicine and sports.

更新日期：2023-05-22

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