Au nanoparticles (AuNPs) is first combined with d-methionine (d-Met) through Au–S bond, and the obtained Au-d-Met was self-assembled with chitosan (CS) via electrostatic driving. Both d-Met and CS are important chiral sources, and therefore the resultant Au-d-Met/CS displays distinct chirality. Interestingly, the chirality of the Au-d-Met/CS can be reversed depending on the ratio of d-Met to CS, as revealed by circular dichroism spectra. Due to the high electrical conductivity of AuNPs as well as the intrinsic chirality of d-Met and CS, the resultant Au-d-Met/CS is used as the electrochemical chiral sensing platform for the discrimination of tryptophan (Trp) enantiomers. Although the Trp enantiomers can be successfully discriminated by the developed chiral sensing platform, the electrochemical signals of l-Trp and d-Trp can be reversed on the differential pulse voltammograms (DPVs) when different ratios of d-Met to CS are used, which can be ascribed to the reversible chirality of the Au-d-Met/CS complexes prepared by different ratios of d-Met to CS.

Au 纳米粒子 (AuNPs) 首先通过 Au-S 键与d-甲硫氨酸 ( d -Met)结合，所获得的 Au- d -Met 通过静电驱动与壳聚糖 (CS) 自组装。d - Met 和 CS 都是重要的手性来源，因此所得的 Aud - Met/CS 显示出明显的手性。有趣的是，Au- d -Met/CS 的手性可以根据d -Met 与 CS 的比率反转，如圆二色光谱所示。由于 AuNPs 的高导电性以及d -Met 和 CS 的内在手性，所得 Au- d-Met/CS 用作区分色氨酸 (Trp) 对映体的电化学手性传感平台。虽然开发的手性传感平台可以成功区分 Trp 对映异构体，但当使用不同比例的d -Met 与 CS 时， l -Trp 和d -Trp 的电化学信号可以在差分脉冲伏安图 (DPV) 上反转，这可归因于通过不同比例的d -Met 与 CS 制备的 Aud- d -Met/CS 复合物的可逆手性。