基于壳聚糖衍生物和氧化海藻酸钠的自交联水凝胶的制备及性能,ACS Omega

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基于壳聚糖衍生物和氧化海藻酸钠的自交联水凝胶的制备及性能
ACS Omega ( IF 3.7 ) Pub Date : 2023-05-20 , DOI: 10.1021/acsomega.3c01401
Guiting Yu ₁ , Chunqing Niu ₂ , Jiali Liu ₁ , Jue Wu _{1,

3} , Zheng Jin _{1,

3} , Yiyu Wang ₃ , Kai Zhao _{1,

3}

Affiliation

自交联和生物相容性水凝胶在组织工程领域具有广泛的应用潜力。在这项工作中，使用自交联方法制备了一种易于获得、可生物降解且有弹性的水凝胶。这种水凝胶由N-2-羟丙基三甲基氯化铵壳聚糖 (HACC) 和氧化海藻酸钠 (OSA)。通过席夫碱自交联和氢键形成稳定可逆的交联网络。屏蔽剂（NaCl）的加入可以减弱HACC与OSA之间强烈的静电效应，解决离子键快速形成引起的絮凝问题，从而延长席夫碱自交联反应的时间。形成均匀的水凝胶。有趣的是，HACC/OSA 水凝胶的最短形成时间在 74 秒以内，并且水凝胶具有均匀的多孔结构和增强的机械性能。由于弹性提高，HACC/OSA 水凝胶可承受较大的压缩变形。更重要的是，这种水凝胶具有良好的溶胀性能，生物降解和保水性。HACC/OSA 水凝胶具有很强的抗菌性能金黄色葡萄球菌和大肠杆菌也表现出良好的细胞相容性。HACC/OSA水凝胶对罗丹明（模型药物）具有良好的缓释作用。因此，本研究获得的自交联HACC/OSA水凝胶在生物医学载体领域具有潜在的应用前景。

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Preparation and Properties of Self-Cross-Linking Hydrogels Based on Chitosan Derivatives and Oxidized Sodium Alginate

A self-cross-linking and biocompatible hydrogel has wide application potential in the field of tissue engineering. In this work, an easily available, biodegradable, and resilient hydrogel was prepared using a self-cross-linking method. This hydrogel was composed of N-2-hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and oxidized sodium alginate (OSA). A stable and reversible cross-linking network was formed by the Schiff base self-cross-linked and hydrogen bonding. The addition of a shielding agent (NaCl) may weaken the intense electrostatic effect between HACC and OSA and solve the problem of flocculation caused by the rapid formation of ionic bonds, which provided an extended time for the Schiff base self-cross-linked reaction for forming a homogeneous hydrogel. Interestingly, the shortest time for the formation of the HACC/OSA hydrogel was within 74 s and the hydrogel had a uniform porous structure and enhanced mechanical properties. The HACC/OSA hydrogel withstood large compression deformation due to improved elasticity. What’s more, this hydrogel possessed favorable swelling property, biodegradation, and water retention. The HACC/OSA hydrogels have great antibacterial properties against Staphylococcus aureus and Escherichia coli and demonstrated good cytocompatibility as well. The HACC/OSA hydrogels have a good sustained release effect on rhodamine (model drug). Thus, the obtained self-cross-linked HACC/OSA hydrogels in this study have potential applications in the field of biomedical carriers.

更新日期：2023-05-20

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