Microchimica Acta ( IF 5.3 ) Pub Date : 2023-05-20 , DOI: 10.1007/s00604-023-05807-x Xiaohui Niu 1 , Rui Zhao 1 , Simeng Yan 1 , Hongxia Li 1 , Jing Yang 2 , Kunjie Cao 1 , Xiaoyu Liu 1 , Kunjie Wang 1
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Abstract
Chiral materials have drawn the widespread attention for their its chiral recognition ability. The design and synthesis of chiral material are of importance owing to the unpredictability in controlling chirality during the synthesis process. To circumvent problems, a chiral MOF (D-His-ZIF-8) was synthesized by ligand exchange of 2-methylimidazole (Hmim) on ZIF-8 by D-histidine (D-His), which can be treated as chiral host to distinguish amino acid enantiomers. The obtained D-His-ZIF-8 can provide chiral nanochannels for amino acid guests. Meanwhile, polynary transition-metal ion (Co2+ and Fe3+) coordinating with polydopamine (PDA) wrapped on the surface of D-His-ZIF-8 can increase the active sites. The electrochemical chiral recognition behavior showed that D-His-ZIF-8@CoFe-PDA exhibited good recognition of the tryptophan enantiomer (L/D-Trp) (working potential of −0.2 V vs. Hg/HgCl2). The LOD and LOQ of L-Trp were 0.066 mM and 0.22 mM, respectively, while the LOD and LOQ of D-Trp were 0.15 mM and 0.50 mM, respectively. Finally, the usefulness of D-His-ZIF-8@CoFe-PDA/GCE was evaluated with a recovery of 94.4–103%. The analysis of real samples shows that D-His-ZIF-8@CoFe-PDA/GCE is a feasible sensing platform for the detection of L-Trp and D-Trp.
Graphical abstract
中文翻译：
手性 MOFs 由具有多金属配位的聚合物封装作为手性生物传感器
摘要
手性材料因其具有手性识别能力而受到广泛关注。由于在合成过程中控制手性的不可预测性，手性材料的设计和合成非常重要。为了规避问题，通过 D-组氨酸 (D-His) 对 ZIF-8 上的 2-甲基咪唑 (Hmim) 进行配体交换，合成了手性 MOF (D-His-ZIF-8)，可以将其视为手性宿主区分氨基酸对映体。获得的 D-His-ZIF-8 可为氨基酸客体提供手性纳米通道。同时，多元过渡金属离子（Co 2+和 Fe 3+) 与包裹在 D-His-ZIF-8 表面的聚多巴胺 (PDA) 配合可以增加活性位点。电化学手性识别行为表明，D-His-ZIF-8@CoFe-PDA对色氨酸对映异构体（L/D-Trp）表现出良好的识别能力（-0.2 V vs. Hg/HgCl 2 工作电位）。L-Trp 的 LOD 和 LOQ 分别为 0.066 mM 和 0.22 mM，而 D-Trp 的 LOD 和 LOQ 分别为 0.15 mM 和 0.50 mM。最后，评估了 D-His-ZIF-8@CoFe-PDA/GCE 的有效性，回收率为 94.4–103%。实际样品分析表明，D-His-ZIF-8@CoFe-PDA/GCE 是检测 L-Trp 和 D-Trp 的可行传感平台。
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