Microgel Assembly Powder Improves Acute Hemostasis, Antibacterial, and Wound Healing via In Situ Co-Assembly of Erythrocyte and Microgel,Advanced Functional Materials

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Microgel Assembly Powder Improves Acute Hemostasis, Antibacterial, and Wound Healing via In Situ Co-Assembly of Erythrocyte and Microgel
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-05-18 , DOI: 10.1002/adfm.202302793
Bingrui Li _{1,

2,

3} , Haofei Li _{1,

2,

3} , Hongjie Chen _{1,

3} , Yang Liu _{1,

4} , Junlin Chen _{1,

4} , Qi Feng _{1,

2,

3,

4} , Xiaodong Cao _{1,

2,

3,

4} , Hua Dong _{1,

2,

3,

4}

Affiliation

Rapid and effective hemostasis on irregular-shaped non-compressible bleeding wounds is still one of the key challenges in clinical practice. Herein, a novel multi-functional microgel assembly powder (MAP) composed of oxidized dextran/methacrylate gelatin (ODex/GelMA) microgel powder and long-chain alkyl quaternized chitosan (LQCS) crosslinker powder is reported for acute hemostasis, antibacterial, and wound healing. When MAP is applied onto bleeding wounds, porous ODex/GelMA microgel powder immediately absorbs massive liquid in blood whilst LQCS induces in situ co-assembly of erythrocytes and microgels. In other words, MAP combines the merits of hemostatic powders and hemostatic hydrogels, that is, the excellent hemostasis performance of MAP is originated from not only the high fluid uptake ratio/rate that causes the aggregation of coagulation factors and erythrocytes, but also the formation of erythrocytes-involved hydrogel-like microgel assembly that dramatically improves the mechanical strength, tissue adhesion and wound sealing performance in blood compared with those in PBS. In addition, MAP also exhibits excellent antibacterial ability, and promotes the wound healing in bacterial-infected full-thickness skin wounds. The fantastic features of MAP including low cost, easy synthesis and usage, excellent hemostasis on irregular-shaped, non-compressible bleeding wounds, outstanding antibacterial and wound healing, good cytocompatibility, make it a promising hemostatic material and wound dressing.

中文翻译：

微凝胶组装粉末通过红细胞和微凝胶的原位共组装改善急性止血、抗菌和伤口愈合

对不规则形状的不可压缩出血伤口的快速有效止血仍然是临床实践中的关键挑战之一。本文报道了一种由氧化葡聚糖/甲基丙烯酸明胶（ODex/GelMA）微凝胶粉末和长链烷基季铵化壳聚糖（LQCS）交联剂粉末组成的新型多功能微凝胶组装粉末（MAP），用于急性止血、抗菌和伤口愈合。当 MAP 应用于流血伤口时，多孔 ODex/GelMA 微凝胶粉末立即吸收血液中的大量液体，而 LQCS 则诱导红细胞和微凝胶原位共组装。也就是说，MAP结合了止血粉和止血水凝胶的优点，即 MAP优异的止血性能不仅源于其高液体摄取率/速率导致凝血因子和红细胞聚集，还源于红细胞参与的水凝胶状微凝胶组件的形成，从而显着提高机械强度、组织粘附力以及血液中与 PBS 中伤口密封性能的比较。此外，MAP还表现出优异的抗菌能力，可促进细菌感染的全层皮肤伤口的愈合。MAP具有成本低廉、易于合成和使用、对不规则形状、不可压缩的出血伤口具有优异的止血效果、优异的抗菌和伤口愈合能力、良好的细胞相容性等优异特性，使其成为一种很有前途的止血材料和伤口敷料。还形成了红细胞参与的水凝胶样微凝胶组件，与 PBS 中的相比，显着提高了血液中的机械强度、组织粘附和伤口密封性能。此外，MAP还表现出优异的抗菌能力，可促进细菌感染的全层皮肤伤口的愈合。MAP具有成本低廉、易于合成和使用、对不规则形状、不可压缩的出血伤口具有良好的止血作用、优异的抗菌和伤口愈合能力、良好的细胞相容性等优点，使其成为一种很有前途的止血材料和伤口敷料。还形成了红细胞参与的水凝胶样微凝胶组件，与 PBS 中的相比，显着提高了血液中的机械强度、组织粘附和伤口密封性能。此外，MAP还表现出优异的抗菌能力，可促进细菌感染的全层皮肤伤口的愈合。MAP具有成本低廉、易于合成和使用、对不规则形状、不可压缩的出血伤口具有优异的止血效果、优异的抗菌和伤口愈合能力、良好的细胞相容性等优异特性，使其成为一种很有前途的止血材料和伤口敷料。MAP还表现出优异的抗菌能力，可促进细菌感染的全层皮肤伤口的愈合。MAP具有成本低廉、易于合成和使用、对不规则形状、不可压缩的出血伤口具有优异的止血效果、优异的抗菌和伤口愈合能力、良好的细胞相容性等优异特性，使其成为一种很有前途的止血材料和伤口敷料。MAP还表现出优异的抗菌能力，可促进细菌感染的全层皮肤伤口的愈合。MAP具有成本低廉、易于合成和使用、对不规则形状、不可压缩的出血伤口具有优异的止血效果、优异的抗菌和伤口愈合能力、良好的细胞相容性等优异特性，使其成为一种很有前途的止血材料和伤口敷料。

更新日期：2023-05-18

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