The correction of errors during mitochondrial DNA replication by the proofreading function of DNA polymerase-γ is crucial for maintaining the integrity of the mitochondrial genome and the production of cellular energy. Using cryo-electron microscopy, several steps of the DNA polymerase-γ proofreading pathway have been revealed at near-atomic resolution.

中文翻译：

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近原子分辨率 DNA 聚合酶-γ 校对动态过程的研究

通过DNA聚合酶-γ的校对功能纠正线粒体DNA复制过程中的错误对于维持线粒体基因组的完整性和细胞能量的产生至关重要。使用冷冻电子显微镜，DNA 聚合酶-γ 校对途径的几个步骤已在近原子分辨率下得以揭示。