Minimally-Invasive and In-Vivo Hydrogel Patterning Method for In Situ Fabrication of Implantable Hydrogel Devices,Small Methods

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Minimally-Invasive and In-Vivo Hydrogel Patterning Method for In Situ Fabrication of Implantable Hydrogel Devices
Small Methods ( IF 10.7 ) Pub Date : 2023-05-18 , DOI: 10.1002/smtd.202300032
Gi Doo Cha _{1,

2,

3} , Minjeong Kim _{1,

2} , Ok Kyu Park _{1,

3} , Sung-Hyuk Sunwoo _{1,

2,

3} , Taegyu Kang _{1,

2} , Wang Hee Lee _{1,

2} , Seonghyeon Nam _{1,

2} , Taeghwan Hyeon _{1,

2} , Seung Hong Choi _{1,

3} , Dae-Hyeong Kim _{1,

2,

4}

Affiliation

Despite advances in a wide range of device applications of hydrogels, including implantable ones, a method for deploying patterned hydrogel devices into the body in a minimally-invasive manner is not available yet. However, in situ patterning of the hydrogel in vivo has an obvious advantage, by which incision surgery for implantation of the hydrogel device can be avoided. Here, a minimally-invasive and in vivo hydrogel patterning method for in situ fabrication of implantable hydrogel devices is presented. The sequential application of injectable hydrogels and enzymes, with assistance of minimally-invasive surgical instruments, enables the in vivo and in situ hydrogel patterning. This patterning method can be achieved by adopting an appropriate combination of the sacrificial mold hydrogel and the frame hydrogel, in consideration of unique material properties of the hydrogels such as high softness, facile mass transfer, biocompatibility, and diverse crosslinking mechanisms. In vivo and in situ patterning of the hydrogels functionalized with nanomaterials is also demonstrated to fabricate the wireless heater and tissue scaffold, showcasing broad applicability of the patterning method.

中文翻译：

用于原位制造可植入水凝胶装置的微创体内水凝胶图案化方法

尽管水凝胶的广泛设备应用（包括植入式水凝胶）取得了进展，但目前还没有一种以微创方式将图案化水凝胶设备部署到体内的方法。然而，水凝胶在体内的原位图案化具有明显的优势，可以避免植入水凝胶装置的切口手术。在这里，提出了一种用于原位制造可植入水凝胶装置的微创体内水凝胶图案化方法。可注射水凝胶和酶的顺序应用，在微创手术器械的帮助下，可以实现体内和原位水凝胶图案化。考虑到水凝胶独特的材料特性，如高柔软度、易于传质、生物相容性和不同的交联机制，这种图案化方法可以通过采用牺牲模具水凝胶和框架水凝胶的适当组合来实现。纳米材料功能化水凝胶的体内和原位图案化也被证明可以制造无线加热器和组织支架，展示了图案化方法的广泛适用性。

更新日期：2023-05-18

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