Microfluidics has been applied in the preparation of monodisperse droplets and microcapsules due to its high encapsulation efficiency, its ability to create uniform particle sizes, and its capacity to control core–shell ratio and structure. To bring to the fore methodologies for the fabrication and application of monodisperse microcapsules using microfluidics, we present a review of the design, structure, materials, and surface modification techniques of various microfluidic chips. The review also covers fabrication methods, operating parameters and regulation methods of single and multiple monodisperse emulsion droplets fabricated from various microfluidic devices. Our findings show that particle size of monodisperse droplets depend mainly on microchannel characteristic size and flow rate, with particle size increasing with larger microchannel but decreasing with higher continuous phase flow rate. We additionally reviewed and compared various fabrication methods for monodisperse microcapsules, such as interfacial polymerization, free-radical polymerization, ionic cross-linking, and solvent evaporation. We further reviewed and examined the application of monodisperse microcapsules in biology applications, food engineering, composite materials development, and pharmaceutical industry. We found that high-throughput microfluidics for scale-up monodisperse microcapsule preparation towards uniform degradation and targeted release properties of monodisperse microcapsules would be key innovative direction for future applications.

中文翻译：

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使用微流控芯片制造单分散液滴和微胶囊：方法和应用综述

微流体由于其高封装效率、产生均匀粒径的能力以及控制核壳比和结构的能力，已被应用于制备单分散液滴和微胶囊。为了突出使用微流控技术制造和应用单分散微胶囊的方法，我们对各种微流控芯片的设计、结构、材料和表面改性技术进行了综述。该综述还涵盖了由各种微流体装置制造的单个和多个单分散乳液液滴的制造方法、操作参数和调节方法。我们的研究结果表明，单分散液滴的粒径主要取决于微通道特征尺寸和流速，粒径随着微通道的增大而增大，但随着连续相流速的升高而减小。我们还回顾和比较了单分散微胶囊的各种制造方法，例如界面聚合、自由基聚合、离子交联和溶剂蒸发。我们进一步回顾和研究了单分散微胶囊在生物学应用、食品工程、复合材料开发和制药工业中的应用。我们发现，用于放大单分散微胶囊制备的高通量微流控技术，实现单分散微胶囊的均匀降解和靶向释放特性，将是未来应用的关键创新方向。我们还回顾和比较了单分散微胶囊的各种制造方法，例如界面聚合、自由基聚合、离子交联和溶剂蒸发。我们进一步回顾和研究了单分散微胶囊在生物学应用、食品工程、复合材料开发和制药工业中的应用。我们发现，用于放大单分散微胶囊制备的高通量微流控技术，实现单分散微胶囊的均匀降解和靶向释放特性，将是未来应用的关键创新方向。我们还回顾和比较了单分散微胶囊的各种制造方法，例如界面聚合、自由基聚合、离子交联和溶剂蒸发。我们进一步回顾和研究了单分散微胶囊在生物学应用、食品工程、复合材料开发和制药工业中的应用。我们发现，用于放大单分散微胶囊制备的高通量微流控技术，实现单分散微胶囊的均匀降解和靶向释放特性，将是未来应用的关键创新方向。我们进一步回顾和研究了单分散微胶囊在生物学应用、食品工程、复合材料开发和制药工业中的应用。我们发现，用于放大单分散微胶囊制备的高通量微流控技术，实现单分散微胶囊的均匀降解和靶向释放特性，将是未来应用的关键创新方向。我们进一步回顾和研究了单分散微胶囊在生物学应用、食品工程、复合材料开发和制药工业中的应用。我们发现，用于放大单分散微胶囊制备的高通量微流控技术，实现单分散微胶囊的均匀降解和靶向释放特性，将是未来应用的关键创新方向。