An antisense RNA, NQO1-AS, binds and stabilizes its sense strand, upregulating the redox enzyme NQO1 in metastatic breast cancer cells. Overexpression of NQO1 facilitates lung colonization by suppressing oxidative stress and ferroptosis, and cancer cells dependent on this pathway can be targeted by a combined therapy that induces ferroptosis while simultaneously inhibiting NQO1.

中文翻译：

---

反义RNA通过上调NQO1促进乳腺癌转移


反义 RNA NQO1-AS 结合并稳定其有义链，上调转移性乳腺癌细胞中的氧化还原酶 NQO1。 NQO1 的过度表达通过抑制氧化应激和铁死亡来促进肺部定植，并且可以通过诱导铁死亡同时抑制 NQO1 的联合疗法来靶向依赖此途径的癌细胞。