Activatable NIR-II Lanthanides-Polymetallic Oxomolybdate Hybrid Nanosensors for Monitoring Chemotherapy Induced Enteritis,Advanced Functional Materials

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Activatable NIR-II Lanthanides-Polymetallic Oxomolybdate Hybrid Nanosensors for Monitoring Chemotherapy Induced Enteritis
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-05-14 , DOI: 10.1002/adfm.202301683
Yuanjin Zhan ₁ , Peng Yu ₁ , Xiaohan Wang ₁ , Yang Xie ₂ , Hongxin Zhang ₁ , Fan Zhang ₁

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Chemotherapy-induced enteritis is one of the side effects associated with cancer therapy, which significantly affects the treatment effect, but there is no effective clinical detection method that can early diagnose its occurrence and progression. Here, a series of second near-infrared window (NIR-II) hybrid nanosensors are designed that consisted of lanthanide nanoparticles and β-Mo2C-derived polymetallic oxomolybdate nanoclusters (Ln@POM). Based on the high sensitivity of POM to reactive oxygen species (ROS) closely related to chemotherapy-induced enteritis, the NIR-II luminescence intensity and lifetime of Ln@POM (Ln: Yb³⁺, Nd³⁺, Ho³⁺, Tm³⁺, Er³⁺) show excellent responsiveness to H₂O₂ and HClO with the detection limit down to 0.15 and 0.14 µm, respectively. Utilizing Nd@POM as a ROS-activated NIR-II nanosensor, the chemotherapeutic enteritis is successfully detected within 7 h after induction of chemotherapy drugs, which is significantly earlier than the gold standard method (immunohistochemistry, 24 h). These results demonstrate that the designed hybrid nanosensors are promising optical tools for the early diagnosis of ROS-related diseases.

中文翻译：

用于监测化疗引起的肠炎的可激活 NIR-II 镧系元素-多金属氧钼酸盐混合纳米传感器

化疗引起的肠炎是癌症治疗的副作用之一，显着影响治疗效果，但临床尚无有效的检测方法可以早期诊断其发生和进展。在这里，设计了一系列第二近红外窗口（NIR-II）混合纳米传感器，由稀土纳米粒子和β -Mo2C衍生的多金属氧代钼酸盐纳米团簇（Ln@POM）组成。基于POM对与化疗引起的肠炎密切相关的活性氧（ROS）的高敏感性，Ln@POM（Ln：Yb 3+ ，Nd 3+ ，Ho 3+ ，Tm）的NIR ^- II^发光强度^和寿命³⁺ , 呃³⁺）对 H ₂ O ₂和 HClO 表现出优异的响应性，检测限分别低至 0.15 和 0.14 µ m。利用Nd@POM作为ROS激活的NIR-II纳米传感器，在化疗药物诱导后7小时内成功检测出化疗性肠炎，明显早于金标准方法（免疫组织化学，24小时）。这些结果表明，设计的混合纳米传感器是用于早期诊断 ROS 相关疾病的有前途的光学工具。

更新日期：2023-05-14

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