Assessing the validity and responsiveness of a generic preference quality of life measure in the context of posttraumatic stress disorder,Quality of Life Research

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Assessing the validity and responsiveness of a generic preference quality of life measure in the context of posttraumatic stress disorder
Quality of Life Research ( IF 3.3 ) Pub Date : 2023-05-14 , DOI: 10.1007/s11136-023-03432-y
Sheradyn R Matthews ₁ , Marja Elizabeth ₁ , Larissa N Roberts ₁ , Billingsley Kaambwa ₂ , Tracey D Wade _{1,

3} , Reginald D V Nixon _{1,

3}

Affiliation

Purpose

There is limited research exploring the usefulness of generic preference-based quality of life (GPQoL) measures used to facilitate economic evaluation in the context of posttraumatic stress disorder (PTSD). The aim of the current study was to explore the validity and responsiveness of a common GPQoL measure (Assessment of Quality of Life 8 Dimension [AQoL-8D]) in relation to a PTSD condition-specific outcome measure (Posttraumatic Stress Disorder Checklist for the DSM-5 [PCL-5]).

Method

This aim was investigated in a sample of individuals (N = 147) who received trauma-focused cognitive-behavioural therapies for posttraumatic stress disorder. Convergent validity was investigated using spearman’s correlations, and the level of agreement was investigated using Bland–Altman plots. Responsiveness was investigated by exploring the standardised response means (SRM) from pre-post-treatment across the two measures, which allow the comparison of the magnitude of change between the measures over time.

Results

Correlations between the AQoL-8D (dimensions, utility and summary total scores) and the PCL-5 total score ranged from small to large and agreement between the measures was considered moderate to good. While SRMs were large for the AQoL-8D and PCL-5 total scores, the SRM for the PCL-5 was nearly double that of the AQoL-8D.

Conclusion

Our findings demonstrate that the AQoL-8D has good construct validity but present preliminary evidence that economic evaluations using only GPQoL measures may not fully capture the effectiveness of PTSD treatments.

中文翻译：

评估创伤后应激障碍背景下一般偏好生活质量测量的有效性和反应性

目的

探索基于偏好的一般生活质量 (GPQoL) 衡量标准用于促进创伤后应激障碍 (PTSD) 背景下经济评估的有用性的研究有限。本研究的目的是探讨常见 GPQoL 测量（生活质量评估 8 维度 [AQoL-8D]）与 PTSD 特定情况结果测量（DSM 创伤后应激障碍检查表）的有效性和反应性-5[PCL-5]）。