<br>情绪障碍问卷的基因检查及其与双相情感障碍的关系,American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

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情绪障碍问卷的基因检查及其与双相情感障碍的关系
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics ( IF 1.6 ) Pub Date : 2023-05-13 , DOI: 10.1002/ajmg.b.32938
Jessica Mundy _{1,

2} , Christopher Hübel _{1,

2,

3} , Brett N Adey _{1,

2} , Helena L Davies _{1,

2} , Molly R Davies _{1,

2} , Jonathan R I Coleman _{1,

2} , Matthew Hotopf _{1,

2,

4} , Gursharan Kalsi _{1,

2} , Sang Hyuck Lee _{1,

2} , Andrew M McIntosh ₅ , Henry C Rogers _{1,

2} , Thalia C Eley _{1,

2} , Robin M Murray ₁ , Evangelos Vassos _{1,

2} , Gerome Breen _{1,

2}

Affiliation

情绪障碍问卷 (MDQ) 是一种常见的双相情感障碍筛查工具，用于评估躁狂症状。它在躁狂症或双相情感障碍遗传研究中的效用尚未得到充分检验。我们对来自英国国家健康与护理研究所心理健康生物资源研究所的参与者的 MDQ 与自我报告的双相情感障碍进行了心理测量比较。我们对源自 MDQ 项目的躁狂症状数量性状和症状亚组进行了全基因组关联研究 ( N = 11,568–19,859)。我们计算了双相情感障碍和其他精神和行为特征的遗传相关性。 MDQ 筛查对自我报告的双相情感障碍显示出较低的阳性预测值 (0.29)。同时发生或终生的躁狂症状均与双相情感障碍没有遗传相关性。终生躁狂症状与创伤后应激障碍具有最高的遗传相关性（ r _g = 1.0），尽管这一点尚未得到队列内表型相关性的证实（ r _p = 0.41）。其他显着的遗传相关性包括注意力缺陷多动障碍（ r _g = 0.69）、失眠（ r _g = 0.55）和重度抑郁症（ r _g = 0.42）。我们的研究补充了质疑 MDQ 有效性的现有文献，并表明它可能捕捉高危人群中一般痛苦或精神病理学的症状，而不是特定的轻躁狂/躁狂症状。

"点击查看英文标题和摘要"

Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder

The Mood Disorder Questionnaire (MDQ) is a common screening tool for bipolar disorder that assesses manic symptoms. Its utility for genetic studies of mania or bipolar traits has not been fully examined. We psychometrically compared the MDQ to self-reported bipolar disorder in participants from the United Kingdom National Institute of Health and Care Research Mental Health BioResource. We conducted genome-wide association studies of manic symptom quantitative traits and symptom subgroups, derived from the MDQ items (N = 11,568–19,859). We calculated genetic correlations with bipolar disorder and other psychiatric and behavioral traits. The MDQ screener showed low positive predictive value (0.29) for self-reported bipolar disorder. Neither concurrent nor lifetime manic symptoms were genetically correlated with bipolar disorder. Lifetime manic symptoms had a highest genetic correlation (r_g = 1.0) with posttraumatic stress disorder although this was not confirmed by within-cohort phenotypic correlations (r_p = 0.41). Other significant genetic correlations included attention deficit hyperactivity disorder (r_g = 0.69), insomnia (r_g = 0.55), and major depressive disorder (r_g = 0.42). Our study adds to existing literature questioning the MDQ's validity and suggests it may capture symptoms of general distress or psychopathology, rather than hypomania/mania specifically, in at-risk populations.

更新日期：2023-05-13

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