Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress,Chemical Communications

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Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress
Chemical Communications ( IF 4.3 ) Pub Date : 2023-05-12 , DOI: 10.1039/d3cc01192e
Mieko Tsuji ₁ , Haruno Taira ₁ , Taro Udagawa ₂ , Tatsuya Aoki ₁ , Tasuku Hirayama ₁ , Hideko Nagasawa ₁

Affiliation

We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon photoirradiation. This study presents a powerful tool for studying redox signaling and oxidative stress in living cells.

中文翻译：

用于光控细胞氧化应激的笼状过氧化物的合成和光化学性质

我们开发了笼式氢过氧化物 BhcTBHP，在蓝光照射下释放促氧化剂 TBHP。MitoTBHP 在第 7 位具有三苯基膦，在光照射下触发线粒体中的选择性氧化应激和膜去极化。这项研究为研究活细胞中的氧化还原信号和氧化应激提供了一个强大的工具。

更新日期：2023-05-16

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