Biodegradable Poly(trehalose) Nanoparticle for Preventing Amyloid Beta Aggregation and Related Neurotoxicity,ACS Applied Bio Materials

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Biodegradable Poly(trehalose) Nanoparticle for Preventing Amyloid Beta Aggregation and Related Neurotoxicity
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2023-05-11 , DOI: 10.1021/acsabm.2c00771
Suman Mandal _{1,

2} , Debabrata Jana _{3,

4} , Jayanta Dolai ₁ , Ankan Kumar Sarkar ₁ , Binay K Ghorai ₄ , Nikhil R Jana ₁

Affiliation

Trehalose is a disaccharide that is capable of inhibiting protein aggregation and activating cellular autophagy. It has been shown that a polymer or nanoparticle form, terminated with multiple trehalose units, can significantly enhance the anti-amyloidogenic performance and is suitable for the treatment of neurodegenerative diseases. Here, we report a trehalose-conjugated polycarbonate-co-lactide polymer and formulation of its nanoparticles having multiple numbers of trehalose exposed on the surface. The resultant poly(trehalose) nanoparticle inhibits the aggregation of amyloid beta peptides and disintegrates matured amyloid fibrils into smaller fragments. Moreover, the poly(trehalose) nanoparticle lowers extracellular amyloid β oligomer-driven cellular stress and enhances cell viability. The presence of biodegradable polycarbonate components in the poly(trehalose) nanoparticle would enhance their application potential as an anti-amyloidogenic material.

中文翻译：

可生物降解的聚（海藻糖）纳米颗粒用于预防淀粉样蛋白 β 聚集和相关的神经毒性

海藻糖是一种双糖，能够抑制蛋白质聚集并激活细胞自噬。已经表明，以多个海藻糖单元终止的聚合物或纳米颗粒形式可以显着增强抗淀粉样蛋白生成的性能，适用于治疗神经退行性疾病。在这里，我们报告了一种海藻糖缀合的聚碳酸酯-co-丙交酯聚合物及其表面暴露有多个海藻糖的纳米颗粒的制剂。由此产生的聚（海藻糖）纳米颗粒可抑制淀粉样蛋白 β 肽的聚集，并将成熟的淀粉样蛋白原纤维分解成更小的碎片。此外，聚（海藻糖）纳米颗粒可降低细胞外淀粉样蛋白 β 寡聚体驱动的细胞应激并增强细胞活力。聚（海藻糖）纳米颗粒中可生物降解的聚碳酸酯成分的存在将增强其作为抗淀粉样蛋白形成材料的应用潜力。

更新日期：2023-05-11

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