Starting from the 5,6-dichloro-2-phenyl-1H-benzimidazole, new benzimidazole derivatives having schiff base, carbothioamide, thiadiazole, and triazole moiety were synthesized and characterized. Synthesized compounds were characterized by NMR spectroscopy, mass spectroscopy and elemental analyses techniques. Antioxidant and elastase inhibitory activities of compounds were also investigated. The inhibitory effects on elastase activity of the synthesized molecules were analyzed spectrophotometrically. The antioxidant activities of molecules were investigated by both methods as DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity and iron reducing power capacities. All synthesized compounds showed good antioxidant and elastase inhibitory activity. Compound 2 showed the highest elastase inhibition. Compound 3 and compound 2 showed the highest antioxidant activity by DPPH method, and iron reducing power method, respectively.

中文翻译：

---

一些 5,6-二氯苯并咪唑衍生物的设计、合成和表征及其抗氧化和弹性蛋白酶抑制活性的研究

以5,6-二氯-2-苯基-1H-苯并咪唑为原料，合成并表征了具有希夫碱、硫硫酰胺、噻二唑和三唑部分的新型苯并咪唑衍生物。通过核磁共振波谱、质谱和元素分析技术对合成的化合物进行了表征。还研究了化合物的抗氧化和弹性蛋白酶抑制活性。通过分光光度法分析合成分子对弹性蛋白酶活性的抑制作用。通过两种方法研究了分子的抗氧化活性，如DPPH（1,1-二苯基-2-三硝基苯肼）自由基清除活性和铁还原能力。所有合成的化合物均表现出良好的抗氧化和弹性蛋白酶抑制活性。化合物2显示出最高的弹性蛋白酶抑制作用。通过DPPH法和铁还原力法，化合物3和化合物2分别显示出最高的抗氧化活性。